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Title: Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda.
Authors: Fogg, Carole;Bajunirwe, Francis;Piola, Patrice;Biraro, Samuel;Checchi, Francesco;Kiguli, James;Namiiro, Proscovia;Musabe, Joy;Kyomugisha, Agnes;Guthmann, Jean-Paul
subject: Adolescent;Animals;Antimalarials;Artemisinins;Children;Child, Preschool;Drug Administration Schedule;Drug Therapy, Combination;Ethanolamines;Female;Fluorenes;Humans;Infant;Malaria, Falciparum;Male;Patient Compliance;Plasmodium falciparum;Questionnaires;Risk Factors;Self Administration;Sesquiterpenes;Uganda
Publisher: Published by: American Society of Tropical Medicine and Hygiene
Description: Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its latest World Health Organization blister formulation. Patients with uncomplicated Plasmodium falciparum malaria were prescribed artemether-lumefantrine and received an explanation of how to take the following five doses at home. A tablet count was made and a questionnaire was completed during a home visit. Among 210 analyzable patients, 21 (10.0%) were definitely or probably non-adherent, whereas 189 (90.0%) were probably adherent. Age group was not associated with adherence. Lack of formal education was the only factor associated with non-adherence after controlling for confounders (odds ratio = 3.1, 95% confidence interval [CI] = 1.1-9.7). Mean lumefantrine blood levels were lower among non-adherent (n = 16) (2.76 microg/mL, 95% CI = 1.06-4.45) than among adherent (n = 171) (3.19 microg/mL, 95% CI = 2.84-3.54) patients, but this difference was not statistically significant. The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations.
Standard no: Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. 2004, 71 (5):525-30 Am. J. Trop. Med. Hyg.
American Journal of Tropical Medicine and Hygiene
Appears in Collections:Malaria

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