Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/124480
Title: A small molecule inhibitor of NF-κB, dehydroxymethylepoxyquinomicin (DHMEQ), suppresses growth and invasion of nasopharyngeal carcinoma (NPC) cells
Authors: Lui, VWY;Tsao, SW;Wong, JHT;Umezawa, K;Ho, Y;Wong, EYL;Ng, MHL;Cheng, SH;Tsang, CM;Chan, ATC
subject: Anti-invasion;Anti-proliferation;Apoptosis;DHMEQ;Nasopharyngeal carcinoma;NF-κB inhibitor
Year: 2010
Publisher: Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Ireland
Description: Despite the demonstrated constitutive activation of NF-κB in nasopharyngeal carcinoma (NPC), the therapeutic potential of targeting this pathway has not been investigated. Here, we employed a small molecule inhibitor of NF-κB, DHMEQ (which mainly blocks nuclear translocation of activated NF-κB) and demonstrated significant inhibition of NPC cell proliferation, migration, invasion, as well as anchorage-independent growth. These antitumor effects were associated with induction of G 2/M cell cycle arrest and apoptosis, and downregulation of NF-κB target genes (EGFR, cyclin D1 and survivin). This first demonstration of therapeutic benefits of NF-κB targeting in NPC implicates the importance of targeting this pathway in NPC. © 2009 Elsevier Ireland Ltd. All rights reserved.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-72149129447&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=287&issue=1&spage=23&epage=32&date=2010&atitle=A+small+molecule+inhibitor+of+NF-kappaB,+dehydroxymethylepoxyquinomicin+(DHMEQ),+suppresses+growth+and+invasion+of+nasopharyngeal+carcinoma+(NPC)+cells
http://hub.hku.hk/handle/10722/124480
Standard no: Cancer Letters, 2010, v. 287 n. 1, p. 23-32
5315442
10.1016/j.canlet.2009.05.022
32
182761
WOS:000273897900003
0304-3835
1
19560263
eid_2-s2.0-72149129447
23
287
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.