Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/124489
Title: An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent
Authors: Poon, CT;Chan, PS;Man, C;Jiang, FL;Wong, RNS;Mak, NK;Kwong, DWJ;Tsao, SW;Wong, WK
subject: Photodynamic therapy;Porphyroid;Ru(II)-polypyridyl;Tumor-imaging;Two-photon
Year: 2010
Publisher: Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio
United States
Description: An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-70449678441&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0162-0134&volume=104&issue=1&spage=62&epage=70&date=2010&atitle=An+amphiphilic+ruthenium(II)-polypyridyl+appended+porphyrin+as+potential+bifunctional+two-photon+tumor-imaging+and+photodynamic+therapeutic+agent
http://hub.hku.hk/handle/10722/124489
Standard no: Journal Of Inorganic Biochemistry, 2010, v. 104 n. 1, p. 62-70
5923210
10.1016/j.jinorgbio.2009.10.004
70
182720
WOS:000272417300008
0162-0134
1
19880187
eid_2-s2.0-70449678441
62
104
Appears in Collections:Department of Anatomy

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