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|Title:||An amphiphilic ruthenium(II)-polypyridyl appended porphyrin as potential bifunctional two-photon tumor-imaging and photodynamic therapeutic agent|
|Authors:||Poon, CT;Chan, PS;Man, C;Jiang, FL;Wong, RNS;Mak, NK;Kwong, DWJ;Tsao, SW;Wong, WK|
|Publisher:||Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio|
|Description:||An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section. © 2009 Elsevier Inc. All rights reserved.|
|Standard no:||Journal Of Inorganic Biochemistry, 2010, v. 104 n. 1, p. 62-70|
|Appears in Collections:||Department of Anatomy|
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