Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/135000
Title: Adiponectin protects rat hippocampal neurons against excitotoxicity
Authors: Qiu, G;Wan, R;Hu, J;Mattson, MP;Spangler, E;Liu, S;Yau, SY;Lee, TMC;Gleichmann, M;Ingram, DK;So, KF;Zou, S
subject: Adiponectin;AMPK;Hippocampus;Kainic acid;Neuroprotection
Year: 2011
Publisher: Springer Netherlands. The Journal's web site is located at http://www.springerlink.com/content/0161-9152/
Netherlands
Description: Adiponectin exerts multiple regulatory functions in the body and in the hypothalamus primarily through activation of its two receptors, adiponectin receptor1 and adiponectin receptor 2. Recent studies have shown that adiponectin receptors are widely expressed in other areas of the brain including the hippocampus. However, the functions of adiponectin in brain regions other than the hypothalamus are not clear. Here, we report that adiponectin can protect cultured hippocampal neurons against kainic acid-induced (KA) cytotoxicity. Adiponectin reduced the level of reactive oxygen species, attenuated apoptotic cell death, and also suppressed activation of caspase-3 induced by KA. Pretreatment of hippocampal primary neurons with an AMPK inhibitor, compound C, abolished adiponectin-induced neuronal protection. The AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, attenuated KA-induced caspase-3 activity. These findings suggest that the AMPK pathway is critically involved in adiponectin-induced neuroprotection and may mediate the antioxidative and anti-apoptotic properties of adiponectin. © 2010 US Government.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-79959544623&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/135000
Standard no: Age, 2011, v. 33 n. 2, p. 155-165
7875707
10.1007/s11357-010-9173-5
165
186214
WOS:000291056200005
0161-9152
2
20842535
eid_2-s2.0-79959544623
155
33
Appears in Collections:Department of Anatomy

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