Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/137204
Title: Molecular changes during arsenic-induced cell transformation
Authors: Li, G;Lee, LS;Li, M;Chiu, JF;Tsao, SW
Year: 2011
Publisher: John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/31010
United States
Description: Arsenic and its derivatives are naturally occurring metalloid compounds widely distributed in the environment. Arsenics are known to cause cancers of the skin, liver, lung, kidney, and bladder. Although numerous carcinogenic pathways have been proposed, the exact molecular mechanisms remain to be delineated. To further characterize the role of oxidative stress in arsenite-induced cell transformation via the reactive oxygen species (ROS)-mediated Ras/Erk pathway, here we demonstrated arsenite-induced rat lung epithelial cell (LEC) transformation, epithelial-mesenchymal transition, stimulation of the extracellular signal-regulated kinase signaling pathway, and enhancement of cell proliferation. However, there was no evidence of activation of the phosphoinositide 3-kinase/protein kinase B pathway in arsenite-induced transformed LECs. Since ROS is involved in arsenite-induced LEC cell transformation, Redox-status regulatory proteins (Cu/Zn SOD and thioredoxin) and arsenite-induced LEC cell transformation were significantly inhibited by concurrent treatment with the antioxidants. Our experimental results clearly demonstrated that induction of p-ERK and cell proliferation by arsenite is mediated via oxidative stress, since antioxidants can inhibit arsenite-induced cell transformation.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-79958140770&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/137204
Standard no: Journal of Cellular Physiology, 2011, v. 226 n. 12, p. 3225-3232
10.1002/jcp.22683
3232
191898
WOS:000296458100015
0021-9541
12
21344382
eid_2-s2.0-79958140770
3225
226
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.