Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/148495
Title: Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1α-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma
Authors: Lee, TK;Poon, RTP;Ling, MT;Wong, YC;Guan, XY;Man, K;Fan, ST;Yuen, AP;Wang, XH;Tang, ZY
Year: 2006
Publisher: American Association for Cancer Research.
United States
Description: Purpose: Metastasis is commonly associated with poor prognosis of hepatocellular carcinoma (HCC). Being an important angiogenic factor, vascular endothelial growth factor (VEGF) plays a central role in HCC growth and metastasis. Recently, Id-1 (inhibitor of differentiation/DNA synthesis) has been suggested to be a key factor in cancer progression but the molecular mechanism remains unknown. Experimental Design: We first showed that overexpression of Id-1 was correlated with HCC metastasis (P < 0.001) and its expression was significantly correlated with VEGF expression by tissue microarray. By ectopic transfection of Id-1 into HCC cells, Id-1 was able to induce VEGF secretion through activation of VEGF transcription. Results: Increased VEGF secretion in Id-1 transfectants induced morphologic change and proliferation of human umbilical vascular endothelial cell resulting in promotion of angiogenesis. Id-1 induced transcriptional activation of VEGF by stabilizing hypoxia-inducible factor-1α protein. Down-regulation of Id-1 by antisense approach led to suppression of hypoxia-inducible factor-1α-mediated VEGF production. In addition, Id-1 suppression resulted in retardation of cell invasion through down-regulation of VEGF. Conclusions: Id-1 is a novel angiogenic factor for HCC metastasis and down-regulation of Id-1 may be a novel target to inhibit HCC metastasis through suppression of angiogenesis. © 2006 American Association for Cancer Research.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-33845760019&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/148495
Standard no: Clinical Cancer Research, 2006, v. 12 n. 23, p. 6910-6919
10.1158/1078-0432.CCR-06-0489
6919
137542
125160
WOS:000242691000007
1078-0432
23
17145808
eid_2-s2.0-33845760019
6910
12
Appears in Collections:Department of Anatomy

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