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Title: GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
Authors: Yuan, Q;Hu, B;Su, H;So, K;Lin, Z;Wu, W
Year: 2009
Publisher: BioMed Central Ltd. The Journal's web site is located at
United Kingdom
Description: Background: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
Standard no: Journal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18
Appears in Collections:Department of Anatomy

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