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|Title:||A lectin with anti-HIV-1 reverse transcriptase, antitumor, and nitric oxide inducing activities from seeds of Phaseolus vulgaris cv. Extralong Autumn Purple Bean|
|Authors:||Fang, EF;Lin, P;Wong, JH;Tsao, SW;Ng, TB|
|Publisher:||American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau|
|Description:||Lectins/hemagglutinins are a class of sugar-binding proteins which agglutinate cells and/or precipitate glycoconjugates. They occur widely in plants but manifest significant differences in activities, which means only a few of them own exploitable potentials. The objective of this study was to find and characterize a multifunctional plant lectin with high potential values in food chemistry and medicine. A 60-kDa lectin from Phaseolus vulgaris L. cv. Extralong Autumn Purple Bean (EAPL) was purified by liquid chromatography, and the sequence of its first 20 N-terminal amino acids was ANEIYFSFQRFNETNLILQR. It was galactose-specific and manifested hemagglutinating activity toward erythrocytes of rabbit, rat, mouse, and human ABO blood types. EAPL manifested anti-HIV1-RT activity, and it could inhibit the proliferation of human tumor cells by inducing the production of apoptotic bodies. The nitric oxide-inducing activity of EAPL may find application in tumor therapy. © 2010 American Chemical Society Phaseolus vulgaris cv. Extralong Autumn Purple Bean, purification, lectin, anti-HIV, antitumor, nasopharyngeal carcinoma, nitric oxide, apoptotic body.|
|Standard no:||Journal Of Agricultural And Food Chemistry, 2010, v. 58 n. 4, p. 2221-2229|
|Appears in Collections:||Department of Anatomy|
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