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Title: Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
Authors: Yuan, Q;Hu, B;Chu, TH;Su, H;Zhang, W;So, KF;Lin, Z;Wu, W
Year: 2010
Publisher: Academic Press. The Journal's web site is located at
United States
Description: Neuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. © 2010 Elsevier Inc.
Standard no: Nitric Oxide - Biology And Chemistry, 2010, v. 23 n. 4, p. 258-263
Appears in Collections:Department of Anatomy

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