Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/159266
Title: LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
Authors: Chua, D;Nicholls, JM;Lung, ML;Chen, H;Ko, JMY;Wong, VCL;Hyytiainen, M;KeskiOja, J;Cheung, FMF;Lee, AWM;Kwong, DLW;Chiu, PM;Zabarovsky, ER;Tsao, SW;Tao, Q;Kan, R;Chan, SHK;Stanbridge, EJ
subject: Anti-angiogenesis;Latent transforming growth factor β binding protein 2 (LTBP-2);Metastatic growth;Nasopharyngeal carcinoma (NPC);Tumor cell dormancy;Tumor suppression
Year: 2012
Publisher: Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Ireland
Description: This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment. © 2012 Elsevier Ireland Ltd.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-84865283257&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/159266
Standard no: Cancer Letters, 2012, v. 325 n. 1, p. 89-98
11279395
10.1016/j.canlet.2012.06.005
98
202596
WOS:000308781600011
0304-3835
1
22743615
eid_2-s2.0-84865283257
89
325
Appears in Collections:Department of Anatomy

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