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|Title:||LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma|
|Authors:||Chua, D;Nicholls, JM;Lung, ML;Chen, H;Ko, JMY;Wong, VCL;Hyytiainen, M;KeskiOja, J;Cheung, FMF;Lee, AWM;Kwong, DLW;Chiu, PM;Zabarovsky, ER;Tsao, SW;Tao, Q;Kan, R;Chan, SHK;Stanbridge, EJ|
|subject:||Anti-angiogenesis;Latent transforming growth factor β binding protein 2 (LTBP-2);Metastatic growth;Nasopharyngeal carcinoma (NPC);Tumor cell dormancy;Tumor suppression|
|Publisher:||Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet|
|Description:||This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment. © 2012 Elsevier Ireland Ltd.|
|Standard no:||Cancer Letters, 2012, v. 325 n. 1, p. 89-98|
|Appears in Collections:||Department of Anatomy|
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