Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/180126
Title: A breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depression
Authors: Wong, GTH;Law, ACK;Chang, RCC
subject: Cytoskeleton;Depression;Microtubule;Post-translational modification;Actin;Tubulin
Year: 2013
Publisher: Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/arr
Ireland
Description: Special issue: Invertebrate Models of Aging
Review article
Depression is one of the most common psychiatric disorders with inadequately understood disease mechanisms. It has long been considered that dendritic regression and decrease in the number of dendritic spines are involved in depression. Dendrites made up of microtubules and actin filaments form synapses with neighboring neurons, which come together as an important communication network. Cytoskeletal proteins undergo post-translational modifications to define their structure and function. In depression and other psychiatric disorders, post-translational modifications may be disrupted that can result in altered cytoskeletal functions. The disruption of microtubule and actin in terms of morphology and functions may be a leading cause of dendritic regression and decrease in dendritic spine in depression.
URI: http://hub.hku.hk/handle/10722/180126
Standard no: Ageing Research Reviews, 2013, v. 12 n. 1, p. 67-75
10.1016/j.arr.2012.08.004
75
212921
WOS:000315125800008
1568-1637
1
22995339
eid_2-s2.0-84867456287
67
12
Appears in Collections:Department of Anatomy

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