Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/188847
Title: Behavioral Stress fails to Accelerate the Onset and Progression of Plaque Pathology in the Brain of a Mouse Model of Alzheimer's Disease
Authors: Yuan, QJ;Su, HX;Chau, WH;Ng, GCT;Huang, JD;Wu, W;Lin, ZX
Year: 2013
Publisher: Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
United States
Description: Conflicting findings exist regarding the link between environmental factors and development of Alzheimer's disease (AD) in a variety of transgenic mouse models of AD. In the present study, we investigated the effect of behavioral stress on the onset and progression of Abeta pathology in the brains of TgCRND8 mice, a transgenic mouse model of AD. One group of TgCRND8 mice was subjected to restraint stress starting at 1 month of age until they were 3 months old, while restraint stress in the second group started at 4 months of age until they were 6 months old. After 2 months of treatment, no differences in the soluble, formic acid extracted, or histologically detected Abeta deposition in the cortical and hippocampal levels were found between non-stressed and stressed mice. These results showed that restraint stress alone failed to aggravate amyloid pathology when initiated either before or after the age of amyloid plaque deposition in TgCRND8 mice, suggesting that if stress aggravated AD phenotype, it may not be via an amyloid-related mechanism in the TgCRND8 mice. These findings are indicative that plaque load per se may not be used as a significant criterion for evaluating the effect of stress on AD patients.
URI: http://hub.hku.hk/handle/10722/188847
Standard no: PLoS One, 2013, v. 8 n. 1, p. e53480
10.1371/journal.pone.0053480
e53480
222730
WOS:000314705800047
1932-6203
1
PMC3543430
23326437
e53480
8
Appears in Collections:Department of Anatomy

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