Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/58229
Title: Serological proteomics of gastritis: Degradation of apolipoprotein A-I and alpha1-antitrypsin is a common response to inflammation irrespective of Helicobacter pylori infection
Authors: He, QY;Yang, H;Wong, BCY;Chiu, JF
Year: 2008
Publisher: Springer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0163-2116
United States
Description: Proteomic technology was employed to analyze serum samples from healthy subjects (10 cases) and gastritis patients with negative and positive Helicobacter pylori (Hp) infection (15 cases each). The serum proteins were separated by two-dimensional (2-D) gel electrophoresis and analyzed by a computer-aided program. The altered proteins in expression were then identified by mass spectrometry and validated by Western blotting. Compared to those in normal control, proteins in at least six areas of 2-D gels were found to significantly increase their expression levels in both Hp-negative and Hp-positive serum samples. These proteins were identified by mass peptide fingerprinting and confirmed by Western blotting to be the truncated or cleaved protein fragments of apolipoprotein A-I and alpha-1 antitrypsin, two well-known acute-phase proteins. We conclude that the degradation or metabolization of acute-phase proteins, apolipoprotein A-I, and alpha1-antitrypsin, is a common response to gastric inflammation irrespective of Hp infection. © 2008 Springer Science+Business Media, LLC.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-55949091399&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/58229
Standard no: Digestive Diseases And Sciences, 2008, v. 53 n. 12, p. 3112-3118
10.1007/s10620-008-0269-z
3118
150114
WOS:000260837000009
0163-2116
12
18594986
eid_2-s2.0-55949091399
3112
53
Appears in Collections:Department of Anatomy

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