Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67345
Title: FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase
Authors: Ling, MT;Man, K;Wong, YC;Zhou, C;KinWah Lee, T;Wang, X
subject: FTY720;Invasion;Prostate Cancer;RhoA
Year: 2006
Publisher: Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Ireland
Description: The failure of controlling androgen-independent and metastatic prostate cancer growth is the main cause of death in prostate cancer patients. In this study, we have demonstrated evidence on the inhibitory effects of a fungus metabolite, FTY720, on the clonogenesity as well as invasion ability of androgen-independent prostate cancer cells. First, using colony forming assay, we found that FTY720 treatment led to decreased colony forming ability of androgen-independent prostate cancer cell lines DU145 and PC3, indicating its negative role on cancer cell survival. In addition, treatment with relatively low dose of FTY720 (i.e. inhibitory concentration of 50% cell survival) resulted in suppression of prostate cancer cell migration and invasion abilities demonstrated by Wound closure, 3D collagen gel invasion assays and stress fiber staining. Furthermore, we found that the inhibitory effect of FTY720 on prostate cancer invasion was associated with down-regulation of GTP-bound active form of RhoA. Transfection of a dominant-active RhoA vector in DU145 and PC3 cells conferred resistance to FTY720. Since activation of RhoA-GTPase is associated with metastasis in many types of malignancies, our results not only suggest a new agent for the treatment of advanced prostate cancer, but also implicate a possible novel anticancer drug especially against metastatic cancers. © 2005 Elsevier Ireland Ltd. All rights reserved.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-32244448999&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3835&volume=233&spage=36&epage=47&date=2006&atitle=FTY720,+a+fungus+metabolite,+inhibits+invasion+ability+of+androgen-independent+prostate+cancer+cells+through+inactivation+of+RhoA-GTPase
http://hub.hku.hk/handle/10722/67345
Standard no: Cancer Letters, 2006, v. 233 n. 1, p. 36-47
10.1016/j.canlet.2005.02.039
47
115049
WOS:000235851300006
0304-3835
1
16473668
eid_2-s2.0-32244448999
36
233
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.