Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67419
Title: Absence or low number of telomere repeats at junctions of dicentric chromosomes
Authors: Wan, TSK;Martens, UM;Poon, SSS;Tsao, SW;Chan, LC;Lansdorp, PM
Year: 1999
Publisher: John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38250
United States
Description: Human ovarian surface epithelial (HOSE) cells transfected with the E6 and E7 oncogenes of the human papilloma virus (PV) do not express measurable telomerase activity. Relative to untransfected control cells, HOSE-PV cells have an extended in vitro lifespan characterized by a very high frequency of telomeric associations (TAs) of chromosomes. In order to study the role of telomere shortening in the formation of TAs, we studied the telomere length in 120 dicentric chromosomes in HOSE-PV cells by using quantitative fluorescence in situ hybridization. Forty percent of the dicentric chromosomes had no fluorescence signal at the junction site, and in the remainder the fluorescence at the junction was less than at corresponding unjoined ends. These observations support a critical role of telomere shortening in the development of TAs and the subsequent genetic instability observed in a majority of tumor cells.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032890295&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1045-2257&volume=24&spage=83&epage=86&date=1999&atitle=Absence+or+low+number+of+telomere+repeats+at+junctions+of+dicentric+chromosomes
http://hub.hku.hk/handle/10722/67419
Standard no: Genes Chromosomes And Cancer, 1999, v. 24 n. 1, p. 83-86
10.1002/(SICI)1098-2264(199901)24:1<83::AID-GCC12>3.0.CO;2-C
86
39152
WOS:000077218900012
1045-2257
1
9892113
eid_2-s2.0-0032890295
83
24
Appears in Collections:Department of Anatomy

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