Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67431
Title: The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells
Authors: Tsao, SW;Liu, Yu;Wang, X;Yuen, PW;Leung, SY;Yuen, ST;Pan, J;Nicholls, JM;Cheung, ALM;Wong, YC
subject: E-cadherin;Methylation;Nasopharyngeal carcinoma
Year: 2003
Publisher: Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca
United Kingdom
Description: Loss of E-cadherin (E-cad) has been associated with progression and poor survival in nasopharyngeal carcinoma (NPC). In this study, we investigated the role of methylation on E-cad inactivation in NPC cell lines, as well as in NPC tissue samples. Using 6 NPC cell lines, we found that methylation of the E-cad 5′ CpG island promoter region was correlated with the loss of both mRNA and E-cad protein expression in these cell lines. In addition, using 29 NPC and 10 non-malignant nasopharyngeal samples, we also observed 5′ CpG methylation of the E-cad gene in 52% (15 out of 29) NPC samples, but in only 10% (1 out of 10) of the non-malignant nasopharyngeal tissues. Our findings indicate that 5′ CpG island methylation of the E-cad gene may play an important part in the inactivation of E-cad in NPC. Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC. © 2003 Elsevier Science Ltd. All rights reserved.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-12244272656&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-8049&volume=39&issue=4&spage=524&epage=531&date=2003&atitle=The+association+of+E-cadherin+expression+and+the+methylation+status+of+the+E-cadherin+gene+in+nasopharyngeal+carcinoma+cells
http://hub.hku.hk/handle/10722/67431
Standard no: European Journal Of Cancer, 2003, v. 39 n. 4, p. 524-531
10.1016/S0959-8049(02)00494-X
531
76254
WOS:000181686800027
0959-8049
4
12751385
eid_2-s2.0-12244272656
524
39
Appears in Collections:Department of Anatomy

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