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|Title:||The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells|
|Authors:||Tsao, SW;Liu, Yu;Wang, X;Yuen, PW;Leung, SY;Yuen, ST;Pan, J;Nicholls, JM;Cheung, ALM;Wong, YC|
|Publisher:||Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/ejca|
|Description:||Loss of E-cadherin (E-cad) has been associated with progression and poor survival in nasopharyngeal carcinoma (NPC). In this study, we investigated the role of methylation on E-cad inactivation in NPC cell lines, as well as in NPC tissue samples. Using 6 NPC cell lines, we found that methylation of the E-cad 5′ CpG island promoter region was correlated with the loss of both mRNA and E-cad protein expression in these cell lines. In addition, using 29 NPC and 10 non-malignant nasopharyngeal samples, we also observed 5′ CpG methylation of the E-cad gene in 52% (15 out of 29) NPC samples, but in only 10% (1 out of 10) of the non-malignant nasopharyngeal tissues. Our findings indicate that 5′ CpG island methylation of the E-cad gene may play an important part in the inactivation of E-cad in NPC. Our results also suggest that reducing the methylation of the E-cad gene may be a potential therapeutic strategy for NPC. © 2003 Elsevier Science Ltd. All rights reserved.|
|Standard no:||European Journal Of Cancer, 2003, v. 39 n. 4, p. 524-531|
|Appears in Collections:||Department of Anatomy|
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