Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67471
Title: Cisplatin-induced p53-independent growth arrest and cell death in cancer cells.
Authors: Wang, X;Liu, Y;Chow, LS;Wong, SC;Tsao, SW;Kwong, DL;Wang, J;Sham, JS;Nicholls, JM
Year: 1999
Publisher: Spandidos Publications. The Journal's web site is located at http://www.spandidos-publications.com/ijo/
Greece
Description: In a recent study, it was shown that DNA damaging agent cisplatin-induced growth arrest and cell death in cancer cells by a pathway sharing some of the characteristics of replicative senescence. The aim of this study was to determine the role of p53, p21WAF1 and p16INK4A proteins in this alternative route to cancer cell death in additional human cancer cell lines. After exposure to cisplatin, all the cell lines underwent growth arrest and expressed the senescence marker senescence-associated beta-galactosidase, but showed none of the features of apoptosis. However, there was no change in p53 protein expression, and neither p21WAF1 nor p16INK4A was expressed before or up to 4 days after cisplatin exposure. These findings provide further evidence that cells carrying mutations resulting in loss of function in the p53 gene can be killed by cisplatin via a p53-independent route with some similarities to replicative senescence, but not apoptosis.
URI: http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1019-6439&volume=15&issue=6&spage=1097&epage=1102&date=1999&atitle=Cisplatin-induced+p53-independent+growth+arrest+and+cell+death+in+cancer+cells
http://hub.hku.hk/handle/10722/67471
Standard no: International Journal Of Oncology, 1999, v. 15 n. 6, p. 1097-1102
1102
47688
WOS:000083902400007
1019-6439
6
10568814
eid_2-s2.0-0033451038
1097
15
Appears in Collections:Department of Anatomy

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