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|Title:||Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum|
|Authors:||So, KF;Chang, RCC;Yu, MS;Ho, YS;Yuen, WH|
|subject:||Cytoprotective effects;Endoplasmic reticulum;Lycium barbarum;Reducing stress|
|Publisher:||Demetrios A Spandidos Ed & Pub. The Journal's web site is located at http://184.108.40.206/IJMM/ijmm.htm|
|Description:||Fulltext link: http://www.pkdiet.com/pdf/food/goji/goji1.pdf|
Chinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor, immune-stimulatory and cytoprotection. Most of these studies emphasized that the protective function of L. barbarum is due to its anti-oxidative effects. We have previously demonstrated that extract from L. barbarum can protect neurons against β-amyloid (Aβ) peptide-induced apoptosis. Since Aβ toxicity may be mediated via oxidative stress, it is still unclear whether the extract from L. barbarum is a simple anti-oxidant exhibiting cytoprotective effects. We hypothesized that extract from L. barbarum is not simply an anti-oxidant in order to function as a neuroprotective agent. The aim of this study is to investigate whether the extract from L. barbarum (LBG) protect neurons via mechanisms independent of anti-oxidative effects. Using a reducing agent, dithiothreitol (DTT), we found that LBG exhibits cytoprotective effects against reducing stress by lowering the DTT-induced LDH release and caspase-3 activity. DTT can trigger endoplasmic reticulum (ER) stress leading to PKR-like ER kinase (PERK) activation. We also showed that LBG attenuates DTT-induced PERK phosphorylation. The extract from L. barbarum is not simply an anti-oxidant; it can also exhibit cytoprotective effects against reducing stress by DTT.
|Standard no:||International Journal Of Molecular Medicine, 2006, v. 17 n. 6, p. 1157-1161|
|Appears in Collections:||Department of Anatomy|
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