Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67474
Title: Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum
Authors: So, KF;Chang, RCC;Yu, MS;Ho, YS;Yuen, WH
subject: Cytoprotective effects;Endoplasmic reticulum;Lycium barbarum;Reducing stress
Year: 2006
Publisher: Demetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Greece
Description: Fulltext link: http://www.pkdiet.com/pdf/food/goji/goji1.pdf
Chinese medicinal herbs have been consumed for thousands of years for the purpose of healthy aging. Lycium barbarum is valued in Chinese culture for its benefits to anti-aging, vision, kidney and liver. Recent studies showed that extracts from L. barbarum possess biological activities including anti-aging, anti-tumor, immune-stimulatory and cytoprotection. Most of these studies emphasized that the protective function of L. barbarum is due to its anti-oxidative effects. We have previously demonstrated that extract from L. barbarum can protect neurons against β-amyloid (Aβ) peptide-induced apoptosis. Since Aβ toxicity may be mediated via oxidative stress, it is still unclear whether the extract from L. barbarum is a simple anti-oxidant exhibiting cytoprotective effects. We hypothesized that extract from L. barbarum is not simply an anti-oxidant in order to function as a neuroprotective agent. The aim of this study is to investigate whether the extract from L. barbarum (LBG) protect neurons via mechanisms independent of anti-oxidative effects. Using a reducing agent, dithiothreitol (DTT), we found that LBG exhibits cytoprotective effects against reducing stress by lowering the DTT-induced LDH release and caspase-3 activity. DTT can trigger endoplasmic reticulum (ER) stress leading to PKR-like ER kinase (PERK) activation. We also showed that LBG attenuates DTT-induced PERK phosphorylation. The extract from L. barbarum is not simply an anti-oxidant; it can also exhibit cytoprotective effects against reducing stress by DTT.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-33745699553&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1107-3756&volume=17&spage=1157&epage=1161&date=2006&atitle=Cytoprotective+effects+of+Lycium+barbarum+against+reducing+stress+on+endoplasmic+reticulum.
http://hub.hku.hk/handle/10722/67474
Standard no: International Journal Of Molecular Medicine, 2006, v. 17 n. 6, p. 1157-1161
1161
148333
117294
1107-3756
6
eid_2-s2.0-33745699553
1157
17
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.