Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67570
Title: Identification of a specifically expressed modified form of novel PSP-94 protein in the secretion of benign prostatic hyperplasia
Authors: Xu, K;Wang, X;Ling, MT;Lee, DTW;Fan, T;Chan, FL;Xuan, JJW;Tsao, SW;Wong, YC
Year: 2003
Publisher: Wiley - V C H Verlag GmbH & Co KGaA.
Germany
Description: Using two-dimensional gel electrophoresis, we investigated the profile of prostatic secretory proteins in human expressed prostatic secretion (EPS) from benign prostate hyperplasia (BPH) patients and compared the patterns with normal controls. We identified three specifically expressed proteins, including prostate secretory protein 61 (PSP61), in EPS from benign BPH patients but absent in normal controls. In addition, we found that PSP61 was a modified isoform of the well-documented PSP-94, which had a perfect matching (100% homology) to the first 61 amino acids of the PSP-94 protein but with a deleted C-terminus. This shortened PSP61 was not due to alternative splicing of the PSP-94 gene at transcription level. Our results provide first evidence on the possibility of using PSP61 as a specific biological marker for diagnosis of BPH.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-0347134732&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0173-0835&volume=24&spage=1311&epage=1318&date=2003&atitle=Identification+of+a+specifically+expressed+modified+form+of+novel+PSP-94+protein+in+the+secretion+of+benign+prostatic+hyperplasia
http://hub.hku.hk/handle/10722/67570
Standard no: Electrophoresis, 2003, v. 24 n. 7-8, p. 1311-1318
1318
76296
WOS:000182693400022
0173-0835
7-8
12707925
eid_2-s2.0-0347134732
1311
24
Appears in Collections:Department of Anatomy

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