Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67666
Title: Synergistic effect of nogo-neutralizing antibody IN-1 and ciliary neurotrophic factor on axonal regeneration in adult rodent visual systems
Authors: So, KF;Yip, HK;Cui, Q;Cho, KS
Year: 2004
Publisher: Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
United States
Description: The presence of Nogo axon regeneration inhibitory molecules in the central nervous system (CNS) and the counteracting effect of IN-1 antibodies have been widely reported. In this study, we examined the effect of IN-1-producing hybridoma cells on axon regeneration in adult rodent retinal ganglion cells (RGCs) after various types of optic nerve (ON) injury, evaluating therein whether ciliary neurotrophic factor (CNTF) potentiated the effect of IN-1. We found that application of IN-1 alone failed to enhance regeneration of intracranially or intraorbitally transected RGC axons in a peripheral nerve (PN) graft. IN-1 hybridoma cells also failed to significantly promote intraorbitally crushed ON axons to reenter the distal part of the ON. However, a combined application of IN-1 and CNTF had a synergistic effect in both intracranial PN and intraorbital ON crush paradigms. This study suggests that the action of IN-1 antibodies in promoting axon regeneration in the CNS could be more effective when coupled with other appropriate factors.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-2442645222&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0897-7151&volume=21 no 5&spage=617&epage=625&date=2004&atitle=Synergistic+effect+of+nogo-neutralizing+antibody+IN-1+and+ciliary+neurotrophic+factor+on+axonal+regeneration+in+adult+rodent+visual+systems
http://hub.hku.hk/handle/10722/67666
Standard no: Journal of Neurotrauma, 2004, v. 21 n. 5, p. 617-625
10.1089/089771504774129946
625
87668
WOS:000221461900012
0897-7151
5
15165369
eid_2-s2.0-2442645222
617
21
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.