Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67786
Title: c-mos Immunoreactivity Aids in the Diagnosis of Gestational Trophoblastic Lesions
Authors: Khoo, US;Ngan, HYS;Chan, KYK;Tsao, SW;Cheung, ANY;Xue, WC;Ip, PPC
subject: C-mos;Choriocarcinoma;Germ cell tumor;Gestational trophoblastic disease;Gynecological neoplasm;Hydatidiform mole
Year: 2004
Publisher: Lippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
United States
Description: C-mos is an important proto-oncogene involved in the mitogen-activating protein kinase pathway. This study was designed to explore c-mos immunoreactivity in gestational trophoblastic lesions and compare it with immunoreactivity in normal placentas as well as other gynecological lesions and germ cell tumors using antibody P-19. The immunohistochemical distribution of c-mos in 159 cases of gynecological lesions and 26 germ cell tumors using formalin-fixed, paraffin-embedded tissues was evaluated. The lesions included 45 (32 complete and 13 partial) hydatidiform moles, 17 choriocarcinomas, 5 placental site trophoblastic tumors, 18 squamous cell carcinomas and 5 adenocarcinomas of the cervix, 11 endometrial carcinomas, 9 ovarian carcinomas, 4 primary peritoneal papillary serous carcinomas, 9 low-grade endometrial stromal sarcomas, 4 epithelioid leiomyomas, 6 leiomyosarcomas, and 26 gem cell tumors (3 embryonal carcinomas, 5 yolk sac tumors, 6 immature teratomas, and 3 mature teratomas from the ovary; 9 testicular seminomas). Twenty-six normal placentas also were included for comparison. Among cases of gestational trophoblastic diseases, c-mos immunoreactivity was found in all hydatidiform moles and choriocarcinomas, but in none of the placental site trophoblastic tumors. The c-mos staining pattern was similar in trophoblastic diseases and normal placentas with strong expression in syncytiotrophoblast, moderate expression in villous intermediate trophoblast, and predominantly negative expression in implantation site intermediate trophoblast, chorionic-type intermediate trophoblast, and villous cytotrophoblast. All the nontrophoblastic tumors, including carcinomas, sarcomas, and germ cell tumors, were negative for c-mos expression. Immunohistochemical detection of c-mos is useful in differentiating choriocarcinoma from placental site trophoblastic tumor and nontrophoblastic tumors of the female genital tract that may sometimes cause problems in differential diagnosis.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-1642271865&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0277-1691&volume=23&issue=2&spage=145&epage=150&date=2004&atitle=c-mos+immunoreactivity+aids+in+the+diagnosis+of+gestational+trophoblastic+lesions
http://hub.hku.hk/handle/10722/67786
Standard no: International Journal Of Gynecological Pathology, 2004, v. 23 n. 2, p. 145-150
10.1097/00004347-200404000-00009
150
86776
WOS:000220452800009
0277-1691
2
15084843
eid_2-s2.0-1642271865
145
23
Appears in Collections:Department of Anatomy

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