Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67797
Title: Synergistic effect of optic and peripheral nerve grafts on sprouting of axon-like processes of axotomized retinal ganglion cells in adult hamsters
Authors: Cho, KS;Xiao, YM;So, KF;Diao, YC;Chung, SK
subject: Axon-like processes;Optic nerve;Peripheral nerve;Retina;Silver staining;Transplantation
Year: 1999
Publisher: Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Ireland
Description: We investigated the sprouting response of retinal ganglion cells (RGCs) following the transplantation of peripheral nerve (PN) and/or optic nerve (ON) into the vitreous of the eye and the intraorbital transection of the optic nerve in hamsters. Our previous results showed that an intravitreal PN graft could induce sprouting of axon-like processes in axotomized RGCS [3] (Cho, E.Y. and So, K.F., Characterization of the sprouting response of axon- like processes from retinal ganglion cells after axotomy in adult hamsters: a model using intravitreal implantation of a peripheral nerve, J. Neurocytol., 21 (1992) 589-603). In this model, we have examined the effect of intravitreal ON graft on the sprouting of RGCs both following a co- transplantation of PN and ON into the vitreous and transplantation of ON alone. The present results show that sprouting is increased by more than two- fold in retinas having PN and ON grafts than a PN graft alone. However, the ON graft by itself rarely induced sprouting in RGCs. These results suggest that the ON graft enhance the number of RGCs to sprout axon-like processes in the presence of PN graft by exerting a synergistic rather than an additive effect, since ON graft alone did not induce sprouting. In addition, no diffusible inhibitory effect of ON graft on PN induced sprouting was observed.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-0033597304&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0304-3940&volume=265&spage=175&epage=178&date=1999&atitle=Synergistic+effect+of+optic+and+peripheral+nerve+grafts+on+sprouting+of+axon-like+processes+of+axotomized+retinal+ganglion+cells+in+adult+hamsters
http://hub.hku.hk/handle/10722/67797
Standard no: Neuroscience Letters, 1999, v. 265 n. 3, p. 175-178
10.1016/S0304-3940(99)00240-2
178
40782
WOS:000080020100007
0304-3940
3
10327159
eid_2-s2.0-0033597304
175
265
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.