Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67811
Title: A novel anticancer effect of garlic derivatives: Inhibition of cancer cell invasion through restoration of E-cadherin expression
Authors: Ling, MT;Tsao, SW;Wong, YC;Chu, Q;Feng, H;Cheung, HW;Wang, X
Year: 2006
Publisher: Oxford University Press. The Journal's web site is located at http://carcin.oxfordjournals.org/
United Kingdom
Description: Metastatic cancer is one of the main causes of cancer-related death since they rarely respond to available treatments. Recently, certain compounds isolated from the dietary supplement, garlic, have shown anti-proliferation effect on cancer cells. The aim of this study was to investigate whether certain garlic derivatives had any effect on the potentially invasive androgen-independent prostate cancer (PCa) cells. Using colony-forming, wound-closure as well as matrigel-invasion assays, we found that two main water-soluble constituents of the garlic, S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), were able to suppress PCa cell proliferation and invasive abilities. This inhibitory effect was associated with induction of mesenchymal to epithelial transition. Most importantly, the SAC and SAMC treatment led to restoration of E-cadherin expression at transcription and protein levels. In contrast, the expression of E-cadherin repressor, Snail, was reduced in the SAC- and SAMC-treated cells. Furthermore, examination of cell lines from other types of cancer (ovarian, nasopharyngeal and esophageal carcinomas) also confirmed that the effect of SAC and SAMC on activation of E-cadherin might be a general effect on human cancer cells. Our results demonstrate a novel anticancer effect of garlic and suggest that certain garlic-derived compounds may be potential agents for suppression of invasive growth through restoration of E-cadherin expression in cancer cells. © 2006 Oxford University Press.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-33750442231&selection=ref&src=s&origin=recordpage
http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0143-3334&volume=27&issue=11&spage=2180&epage=2189&date=2006&atitle=A+novel+anticancer+effect+of+garlic+derivatives:+inhibition+of+cancer+cell+invasion+through+restoration+of+E-cadherin+expression
http://hub.hku.hk/handle/10722/67811
Standard no: Carcinogenesis, 2006, v. 27 n. 11, p. 2180-2189
921311
10.1093/carcin/bgl054
2189
127164
WOS:000241629700005
0143-3334
11
16675472
eid_2-s2.0-33750442231
2180
27
Appears in Collections:Department of Anatomy

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