Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/67873
Title: Major biological effects of neurotrophic factors on retinal ganglion cells in mammals
Authors: Cui, Q;So, KF;Yip, HK
Year: 1998
Publisher: S Karger AG. The Journal's web site is located at http://www.karger.com/NSG
Switzerland
Description: The mammalian visual system, particularly retinal ganglion cells, has been used for studying the functions of neurotrophic factors on neurons for many years. The major biological effects of neurotrophic factors on retinal ganglion cells observed so far are the promotion of viability and axonal regeneration. However, there are still some controversies regarding the effects of neurotrophic factors on retinal ganglion cells in the literature. This review is aimed to summarize the available information on the biological actions of these neurotrophic factors on survival and axonal regeneration of retinal ganglion cells and the expressions of neurotrophic factor receptors in the retina. Generally, brain-derived neurotrophic factor, neurotrophin-4/5, fibroblast growth factor and glial cell line-derived neurotrophic factor increase the survival of retinal ganglion cells while the effect of ciliary neurotrophic factor on the viability of adult retinal ganglion cells is controversial. The ciliary neurotrophic factor is the only effective factor in promoting long distance axonal regeneration of retinal ganglion cells whereas brain-derived neurotrophic factor and neurotrophin-4/5 only enhance neurite sprouting within the retina.
URI: http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1422-4933&volume=7&spage=220&epage=226&date=1998&atitle=Major+biological+effects+of+neurotrophic+factors+on+retinal+ganglion+cells+in+mammals
http://hub.hku.hk/handle/10722/67873
Standard no: Biological Signals And Receptors, 1998, v. 7 n. 4, p. 220-226
226
37590
WOS:000075823300002
1422-4933
4
9730581
eid_2-s2.0-0031706057
220
7
Appears in Collections:Department of Anatomy

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