Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/90894
Title: Clinical and pathological significance of the integrin α5β1 expression in endometrial adenocarcinoma
Authors: Li, J;Lin, B;Zhang, X-R;Gao, T;Zhao, Z-H
subject: Endometrial Adenocarcinoma;Immunohistochemistry;Integrin Α5β1
Year: 2001
Description: Purpose: To investigate the integrin α5β1 expression in endometrial adenocarcinoma and its relation with tumor differentiation, invasion, metastasis and prognosis. Methods: The integrin α5β1 expression was detected in 92 cases of endometrial adenocarcinoma by immunohistochemistry technique (PAP method). Results: The expression of integrin α5β1 in 77.1% cases with endometrial adenocarcinoma were weaker or loss. The positive rate of integrin α5β1 was lower in poorly differentiated carcinoma group than in well differentiated group (P < 0.05). The positive rate of integrin α5β1 was lower in lymph-node metastatic group than in nonmetastatic group (P < 0.05). The five-year survival rate of integrin α5β1 positive group was higher in integrin α5β1 positive group (78.4%) than that in negative group (19.2%, P< 0.05). Conclusions: The weak or loss expression of integrin α5β1 was correlated with differentiation and metastasis of endometrial adenocarcinoma. The expression of integrin α5β1 may have prognostic value.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-0042823480&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/90894
Standard no: Fudan University Journal of Medical Sciences, 2001, v. 28 n. 3, p. 251-253
253
1672-8467
3
eid_2-s2.0-0042823480
251
28
Appears in Collections:Department of Anatomy

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