Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/90895
Title: Integrin-driven actin polymerization consolidates long-term potentiation
Authors: Kramár, EA;Lin, B;Rex, CS;Gall, CM;Lynch, G
subject: Species Index: Animalia
Year: 2006
Publisher: National Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Description: Long-term potentiation (LTP), like memory, becomes progressively more resistant to disruption with time after its formation. Here we show that threshold conditions for inducing LTP cause a rapid, long-lasting increase in polymerized filamentous actin in dendritic spines of adult hippocampus. Two independent manipulations that reverse LTP disrupted this effect when applied shortly after induction but not 30 min later. Function-blocking antibodies to β1 family integrins selectively eliminated both actin polymerization and stabilization of LTP. We propose that the initial stages of consolidation involve integrin-driven events common to cells engaged in activities that require rapid morphological changes. © 2006 by The National Academy of Sciences of the USA.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-33645795737&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/90895
Standard no: Proceedings of the National Academy of Sciences of the United States of America, 2006, v. 103 n. 14, p. 5579-5584
10.1073/pnas.0601354103
5584
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WOS:000236636400061
0027-8424
14
PMC1459396
16567651
eid_2-s2.0-33645795737
5579
103
Appears in Collections:Department of Anatomy

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