Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/90944
Title: Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension
Authors: Lin, B;Waterman, R;Lippton, H
subject: Species Index: Animalia
Year: 1999
Publisher: Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Description: The purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-0002418273&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/90944
Standard no: Life Sciences, 1999, v. 66 n. 6, p. PL99-PL104
10.1016/S0024-3205(99)00627-X
PL104
WOS:000084726800012
0024-3205
6
10794074
eid_2-s2.0-0002418273
PL99
66
Appears in Collections:Department of Anatomy

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.