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|Title:||Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension|
|Authors:||Lin, B;Waterman, R;Lippton, H|
|subject:||Species Index: Animalia|
|Publisher:||Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie|
|Description:||The purpose of the present study was to investigate the effects of L- N5-(1-iminoethyl)-ornithine hydrochloride (L-NIO), an inhibitor of nitric oxide (NO) formation, and [Phe1-Ψ(CH2-NH)-Gly2]Nociceptin(1-13)-NH2 (Phe-NOC), a nociceptin receptor antagonist, on the systemic vasodepressor response to nociceptin in the anesthetized rat. The systemic vasodepressor response to bolus intravenous (i.v.) injections of nociceptin was significantly reduced by L-NIO and Phe-NOC. The present data suggest activation of nociceptin receptors dilates the systemic vascular bed through a NO-dependent pathway. These data also demonstrate Phe-NOC is an efficacious and selective nociceptin receptor antagonist in vivo.|
|Standard no:||Life Sciences, 1999, v. 66 n. 6, p. PL99-PL104|
|Appears in Collections:||Department of Anatomy|
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