Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/10722/91077
Title: Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: Striking similarities and obvious differences with mammals
Authors: Lin, B;Chen, S;Cao, Z;Mo, D;Dong, M;Liu, Z;Xu, A;Lin, Y;Zhang, H;Gu, J
subject: Species Index: Aeromonas Salmonicida;Danio Rerio;Mammalia;Negibacteria;Posibacteria;Staphylococcus Aureus
Year: 2007
Publisher: Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/molimm
Description: Zebrafish has emerged as a valuable model for immunological studies. However, little is known about the overall picture of its immune response to infectious pathogens. Here we present the first systematic study of its immune response to Aeromonas salmonicida and Staphylococcus aureus, a Gram-negative and a Gram-positive bacteria, respectively. Genes induced upon infection were identified with suppression subtractive hybridization, with many of them encoding acute phase proteins (APPs). When compared with mammals, striking similarities and obvious differences have been observed. Both similar APPs (SAA, hepcidin and haptoglobin, etc.) and a similar system for the induction of APPs (which involves the TLRs, pro-inflammatory cytokines and C/EBPs) were identified, implying evolutionary conserved mechanisms among fish and mammals. Some novel APPs were also discovered, suggesting different immune strategies adopted by fish species. Among which, LECT2 was induced by up to 1000-fold upon infection, shedding new lights on the function of this gene. Our results constitute the first demonstration of a similar while different immune response in zebrafish and open new avenues for the investigation of evolutionary conserved and fish specific mechanisms of innate immunity. © 2006 Elsevier Ltd. All rights reserved.
URI: http://www.scopus.com/mlt/select.url?eid=2-s2.0-33748193069&selection=ref&src=s&origin=recordpage
http://hub.hku.hk/handle/10722/91077
Standard no: Molecular Immunology, 2007, v. 44 n. 4, p. 295-301
10.1016/j.molimm.2006.03.001
301
WOS:000241460900004
0161-5890
4
16630661
eid_2-s2.0-33748193069
295
44
Appears in Collections:Department of Anatomy

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