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|Title:||Survival analysis of 1148 women diagnosed with breast cancer in Southern Iran|
|Authors:||Rezaianzadeh, A;Peacock, J;Reidpath, DD;Talei, A;Hosseini, SV|
|Description:||Background: While there has been much research regarding risk factors and prognostic factors
for breast cancer in general, research specific to Iran is sparse. Further, the association between
breast cancer survival and socio-demographic and pathologic factors has been widely studied but
the majority of these studies are from developed countries. Southern Iran has a population of
approximately 4 million. To date, no research has been performed to determine breast cancer
survival and to explore the association between the survival and socio-demographic and pathologic
factors in Southern Iran, where this study was conducted.
Methods: The data were obtained from the cancer registry in Fars province, Southern Iran and
included 1148 women diagnosed with breast cancer between 2000 and 2005. The association
between survival, and sociodemographic and pathological factors, distant metastasis at diagnosis,
and treatment options was investigated using Cox regression.
Results: The majority of patients were diagnosed with an advanced tumour size. Five-year overall
survival was 58% (95%CI; 53%–62%). Cox regression showed that family income (good vs poor:
hazard ratio 0.46, 95%CI; 0.23–0.90) smoking (HR = 1.40, 95%CI; 1.07–1.86), metastases to bone
(HR = 2.25, 95%CI; 1.43–3.52) and lung (HR = 3.21, 95%CI;1.70–6.05), tumour size ( 2 cm vs 5
cm: HR = 2.07, 95%CI;1.39–3.09) and grade (poorly vs well differentiated HR = 2.33, 95%CI; 1.52–
3.37), lymph node ratio (0 vs 1: HR = 15.31, 95%CI; 8.89–26.33) and number of involved node (1
vs >15: HR = 14.98, 95%CI; 8.83–25.33) were significantly related to survival.
Conclusion: This is the first study to evaluate breast cancer survival in Southern Iran and has used
a wide range of explanatory factors, 44. The results demonstrate that survival is relatively poor and
is associated with diagnosis with late stage disease. We hypothesise that this is due to low level of
awareness, lack of screening programs and subsequent late access to treatment.|
Brunel Open Access Publishing Fund
|Standard no:||BMC Cancer. 9: 168|
|Appears in Collections:||Dept of Clinical Sciences Research Papers|
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