Please use this identifier to cite or link to this item:
Title: Asthma-like features and clinical course of COPD: an analysis from the Hokkaido COPD cohort study
Authors: Suzuki, Masaru;Makita, Hironi;Konno, Satoshi;Shimizu, Kaoruko;Kimura, Hiroki;Kimura, Hirokazu;Nishimura, Masaharu
subject: asthma–COPD overlap syndrome;atopy;blood eosinophilia;bronchodilator reversibility
Year: 2016
Abstract: RATIONALE Some patients with COPD have asthma-like features, such as significant bronchodilator reversibility, blood eosinophilia, and/or atopy, even if they are not clinically diagnosed as having asthma. However, the clinical significance of asthma-like features overlapping with COPD remains unclear. The aim of this study was to assess the effect of asthma-like features on the clinical course of COPD patients who were adequately treated and followed-up over 10 years. METHODS A total of 268 COPD patients who had been clinically considered as not having asthma by respiratory specialists were included in this study. The asthma-like features included in this study were bronchodilator reversibility (ΔFEV1 ≥12% and ≥200 mL); blood eosinophilia (≥300 cells/µL); and atopy (positive specific IgE for any inhaled antigen). Annual change in post-bronchodilator FEV1 and COPD exacerbation were monitored during the first 5 years; mortality was followed-up during the entire 10 years. RESULTS Fifty-seven subjects (21%) had bronchodilator reversibility, 52 (19%) had blood eosinophilia, and 67 (25%) had atopy. Subjects with blood eosinophilia had significantly slower annual post-bronchodilator FEV1 decline; bronchodilator reversibility and atopy did not affect the annual post-bronchodilator FEV1 decline and none of the asthma-like features were associated with development of COPD exacerbation. Even if subjects had two or more asthma-like features, they displayed similar annual post-bronchodilator FEV1 decline and exacerbation rates and a 10-year mortality rate that was less than subjects with ≤1 asthma-like features (p=0.02). CONCLUSION The presence of asthma-like features was associated with better clinical course in COPD patients under appropriate treatment.
volume: Volume 194
issue: Issue 11
month: December
Appears in Collections:American Journal of Respiratory_Critical Care Medicine 2016

Files in This Item:
File Description SizeFormat 
2016 AJRCC Volume 194 Issue 11 December (6).pdf654.34 kBAdobe PDFThumbnail
Download    Request a copy

Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.