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PreviewIssue DateTitleContributor(s)
2017 JMC Volume 60 Issue 24 December (11).pdf.jpg2017Discovery and Optimisation of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 <sup>L265P</sup> Diffuse Large B-Cell Lymphoma.Scott, James S.; Degorce, Sébastien L.; Anjum, Rana; Culshaw, Janet; Davies, Robert M. D.; Davies, Nichola L; Dillman, Keith S.; Dowling, James E; Drew, Lisa; Ferguson, Andrew D.; Groombridge, Sam D; Halsall, Christopher T.; Hudson, Julian a.; Lamont, Scott; Lindsay, N
2017 JMC Volume 60 Issue 24 December (7).pdf.jpg2017Discovery and optimization of thiazolidinyl- and pyrrolidinyl- derivatives as inhaled PDE4 inhibitors for respiratory diseasesCarzaniga, Laura; Amari, Gabriele; Rizzi, Andrea; Capaldi, Carmelida; De Fanti, Renato; Ghidini, Eleonora; Villetti, Gino; Carnini, Chiara; Moretto, Nadia; Facchinetti, Fabrizio; Caruso, Paola; Marchini, Gessica; Battipaglia, Loredana; Patacchini, Riccardo; Cenacchi, V
2017 JMC Volume 60 Issue 24 December (12).pdf.jpg2017Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and In-Silico TechniquesDi Lello, Paola; Pastor, Richard; Murray, Jeremy M.; Blake, Robert a.; Cohen, Frederick; Crawford, Terry D; Drobnick, Joy; Drummond, Jason; Kategaya, Lorna; Kleinheinz, Tracy; Maurer, Till; Rouge, Lionel; Zhao, Xianrui; Wertz, Ingrid; Ndubaku, Chudi; Tsui, Vickie
2017 JMC Volume 60 Issue 24 December (15).pdf.jpg2017Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance.Lin, Shuimu; Sin, Wan Ling Wendy; Koh, Jun-Jie; Lim, Fanghui; Wang, Lin; Cao, Derong; Beuerman, Roger W; Ren, Li; Liu, Shouping
2017 JMC Volume 60 Issue 24 December (20).pdf.jpg2017Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2Liu, Qiufeng; Huang, Fubao; Yuan, Xiaojing; Wang, Kai; Zou, Yi; Shen, Jianhua; Xu, Yechun
2017 JMC Volume 60 Issue 24 December (16).pdf.jpg2017GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)Romero, F. Anthony; Murray, Jeremy; Lai, Kwong Wah; Tsui, Vickie; Albrecht, Brian K.; An, Le; Beresini, Maureen H.; De Leon Boenig, Gladys; Bronner, Sarah M.; Chan, Emily W.; Chen, Kevin X.; Chen, Zhongguo; Choo, Edna F.; Clagg, Kyle; Clark, Kevin; Crawford, Terry D.; Cy
2017 JMC Volume 60 Issue 24 December (21).pdf.jpg20174-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group are Active against Drug Resistant <i>Plasmodium falciparum</i> and Exhibit Oral Activity in MiceJoshi, Mukesh C.; Okombo, John; Nsumiwa, Samkele; Ndove, Jeffrey; Taylor, Dale; Wiesner, Lubbe; Hunter, Roger; Chibale, Kelly; Egan, Timothy J
2017 JMC Volume 60 Issue 24 December (8).pdf.jpg2017Amino Terminal Copper and Nickel Binding Motif Derivatives of Ovisprin-3 Display Increased Antimicrobial Activity via Lipid OxidationAlexander, Jessica L; Yu, Zhen; Cowan, James a.
2017 JMC Volume 60 Issue 24 December (3).pdf.jpg2017Potential Strategies to Target Protein–Protein Interactions in the DNA Damage Response and Repair PathwaysFujii, Naoaki
2017 JMC Volume 60 Issue 24 December (13).pdf.jpg2017Insulin-Like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological ActivitiesMachackova, Katerina; Collinsová, Michaela; Chrudinová, Martina; Selicharová, Irena; Picha, Jan; Buděšínský, Miloš; Vanek, Vaclav; Zakova, Lenka; Brzozowski, Andrzej Marek; Jiracek, Jiri
2017 JMC Volume 60 Issue 24 December (19).pdf.jpg2017Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatmentXie, Jingjing; Si, Xiaojia; Gu, Shoulai; Wang, Mingliang; Shen, Jian; Li, Haoyan; Shen, Jian; Li, Dan; Fang, Yanjia; Liu, Cong; Zhu, Jidong
2017 JMC Volume 60 Issue 24 December (24).pdf.jpg2017Members contact:-
2017 JMC Volume 60 Issue 24 December (6).pdf.jpg2017Discovery of Tropifexor ( LJN452 ), a Highly Potent Non-Bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis ( NASH )Tully, David C.; Rucker, Paul V.; Chianelli, Donatella; Williams, Jennifer; Vidal, Agnes; Alper, Phil B.; Mutnick, Daniel; Bursulaya, Badry; Schmeits, James; Wu, Xiangdong; Bao, Dingjiu; Zoll, Jocelyn; Kim, Young; Groessl, Todd; Mcnamara, Peter; Martin, H; Molteni, Valen
2017 JMC Volume 60 Issue 24 December (10).pdf.jpg2017Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in RatsWu, Jinhua; Cippitelli, Andrea; Zhang, Yaohong; Debevec, Ginamarie; Schoch, Jennifer; Ozawa, Akihiko; Yu, Yongping; Liu, Huan; Chen, Wenteng; Houghten, Richard a.; Welmaker, Gregory S.; Giulianotti, Marc a.; Toll, Lawrence
2017 JMC Volume 60 Issue 24 December (1).pdf.jpg2017Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) StudiesSpinelli, Francesco; Capparelli, Elena; Abate, Carmen; Colabufo, Nicola a.; Contino, Marialessandra
2017 JMC Volume 60 Issue 24 December (23).pdf.jpg2017Novel Molecules To Treat Chronic Central Nervous System ToxoplasmosisKortagere, Sandhya
2017 JMC Volume 60 Issue 24 December (9).pdf.jpg2017Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by <i>Toxoplasma gondii</i>Rutaganira, Florentine U.; Barks, Jennifer; Dhason, Mary Savari; Wang, Qiuling; Lopez, Michael S.; Long, Shaojun; Radke, Joshua B.; Jones, Nathaniel G.; Maddirala, Amarendar R.; Janetka, James W.; El Bakkouri, Majida; Hui, Raymond; Shokat, Kevan M.; Sibley, L. David
2017 JMC Volume 60 Issue 24 December (18).pdf.jpg2017Structure–Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use DisordersZou, Mu-Fa; Cao, Jianjing; Abramyan, Ara M.; Kopajtic, Theresa; Zanettini, Claudio; Guthrie, Daryl a.; Rais, Rana; Slusher, Barbara S.; Shi, Lei; Loland, Claus J.; Newman, Amy Hauck
2017 JMC Volume 60 Issue 24 December (5).pdf.jpg2017Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization ApproachAnumala, Upendra Rao; Waaler, Jo; Nkizinkiko, Yves; Ignatev, Alexander; Lazarow, Katina; Lindemann, Peter; Olsen, Petter Angell; Murthy, Sudarshan; Obaji, Ezeogo; Majouga, Alexander G.; Leonov, Sergey; von Kries, Jens Peter; Lehtiö, Lari; Krauss, Stefan; Nazaré, Marc
2017 JMC Volume 60 Issue 24 December (22).pdf.jpg2017Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial EvaluationTaban, Ismail M.; Elshihawy, Hosam E. a. E.; Torun, Beyza; Zucchini, Benedetta; Williamson, Clare J.; Altuwairigi, Dania; Ngu, Adeline S. T.; McLean, Kirsty J.; Levy, Colin W.; Sood, Sakshi; Marino, Leonardo B.; Munro, Andrew W.; de Carvalho, Luiz Pedro S.; Simons, Cl