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Title: Agents Acting on the Central Nervous System: Part IX - S,6-Disubstituted6,7,8,9-Tetrahydro-sH-benzocyc1oheptenes& 8,9-Dihydro-7 H-benzocyc1oheptadiene
subject: Heptenols;NMR studies;benzocyclohepten;transisomers
Year: 1968
Description: A series of 6-tertiaryamino-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ones and their corresponding heptenols, 8,9-dihydro-7H-benzocyloheptadiene[6,5-d]pyrazoles, and isoxazoles has been prepared and tested for their pharmacological activity. It has been shown that in reduction of 6-tertiaryamino-6,7,8;9-tetrahydro-5H-benzocyclohepten-5-.ones both the cis- and transisomers are formed, the structure of which have been assigned on the basis of NMR studies. 6-(4-N-methylpiperazinyl) -6,7,8,9-tetrahydro-5H -benzocyclohepten-5-one has been found to possess marked adrenolytic activity, while 6-(4-morpholinyl)-6,7,8,9-tetrahydro-5H-benzocyclohepten- 5-one and the corresponding heptenol shows central depressant action.
Standard no: Indian Journal of Chemistry, 6,1968,6
Appears in Collections:Medicinal and Process Chemistry

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