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|Title:||Drugs Acting on CNS: Syntheses of 2-Substituted& 2,3-Disubstituted Benzo( 6,7) quinazoline-4 -ones.|
|Authors:||GUPTA, C M;BHADURI, A P;KHANNA, K M|
|subject:||CNS depressants;sodium hydroxide;2-Substituted;2,3-disubstituted|
|Description:||A series of 2-substituted and 2,3-disubstituted benzo(6,7)quinazoline-4-ones have been synthesized as possible CNS depressants. 2-Substituted products, viz. hydrazino, phenylhydrazino and amino, have been obtained by the reaction of 2-ethylthio-benzo(6,7) quinazolin-4-one with hydrazine, phenylhydrazine, and primary and secondary amines. The 2,3-disubstituted derivatives have been obtained by the reaction of 2-mercapto-3-phenyl-benzo(6,7)quinazoline- 4-one with appropriate alkyl, arylalkyl, dialkylamino-alkyl halides in the presence of alcoholic sodium hydroxide. Some of the compounds exhibit CNS-depressant activity at high dosage.|
|Standard no:||Indian journal of chemistry,6,1968,621,623.|
|Appears in Collections:||Medicinal and Process Chemistry|
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