Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/231230
Title: Acquired C1 Inhibitor Deficiency
Authors: Otani, Iris M.;Banerji, Aleena
Year: 2017
Publisher: Elsevier Inc
Abstract: Acquired angioedema due to C1-INH deficiency (C1-INH-AAE) can occur when there are acquired (not inherited) deficiencies of C1-INH. A quantitative or functional C1-INH deficiency with negative family history and low C1q is diagnostic of C1-INH-AAE. The most common conditions associated with C1-INH-AAE are autoimmunity and B-cell lymphoproliferative disorders. A diagnosis of C1-INH-AAE can precede a diagnosis of lymphoproliferative disease and confers an increased risk for developing non-Hodgkin lymphoma. Treatment focuses on symptom control with therapies that regulate bradykinin activity (C1-INH concentrate, icatibant, ecallantide, tranexamic acid, androgens) and treatment of any underlying conditions.
URI: http://dl.umsu.ac.ir/handle/Hannan/231230
volume: Volume 37
issue: Issue 3
month: August
Appears in Collections:Immunology and Allergy Clinics of North America 2017

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