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Title: Intramolecular 5-endo-Trig Aminopalladation of β-hydroxy-γ-alkenylamine: Efficient Route to a Pyrrolidine Ring and Its Application for the Synthesis of (-)-8,8a-di-epi-swainsonine
Authors: Singh, Priyanka;Panda, Gautam
subject: Aminopalladation;β-hydroxy-γ-alkenylamine;Pyrrolidine Ring;8a-di-epi-swainsonine
Year: 2014
Description: The intramolecular aminopalladation reaction of L-serine derived β-hydroxy--alkenylamines undergoes 5-endo-trig cyclization to furnish pyrrolidine rings in high yields. The pyrrolidine thus obtained were elaborated to the synthesis of (-)-8,8a-di-epi-swainsonine, a specific and competitive inhibitor (Ki value 2 × 10-6 M) of lysosomal α-mannosidases.
Standard no: RSC Advances, 2014, 4, 2161-2166
Appears in Collections:Medicinal and Process Chemistry

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