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|Title:||Efficient Stereocontrolled Synthesis of Sitagliptin Phosphate|
|Authors:||Subbaiah, C S;Haq, W|
|subject:||Sitagliptin phosphate;Type 2 diabetes mellitus;Stereocontrolled alkylation;Asymmetric synthesis|
|Description:||Synthesis of sitagliptin phosphate 1, a novel DPP-IV inhibitor for the treatment of type 2 diabetes mellitus has been accomplished starting from chiral synthon (1,4-bis[(R)-1-phenylethyl]piperazine-2,5-dione) 2, involving high stereocontrolled (>98%) alkylation as a key step, in a good overall yield of 50% over six steps.|
|Standard no:||Tetrahedron: Asymmetry,2014, 25(13–14), 1026–1030|
|Appears in Collections:||Medicinal and Process Chemistry|
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