Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/25343
Title: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution
Authors: Lindgren, Cecilia M.;Heid, Iris M.;Randall, Joshua C.;Lamina, Claudia;Steinthorsdottir, Valgerdur;Speliotes, Elizabeth K.;Thorleifsson, Gudmar;Willer, Cristen J.;Herrera, Blanca M.;Jackson, Anne U.;Lim, Noha;Scheet, Paul;Soranzo, Nicole;Amin, Najaf;Aulchenko, Yurii S.;Chambers, John C.;Drong, Alexander;Luan, Jian'an;Rivadeneira, Fernando;Sanna, Serena;Timpson, Nicholas J.;Zillikens, M. Carola;Almgren, Peter;Bandinelli, Stefania;Bennett, Amanda J.;Bergman, Richard N.;Bonnycastle, Lori L.;Bumpstead, Suzannah J.;Chanock, Stephen J.;Cherkas, Lynn;Chines, Peter;Coin, Lachlan;Cooper, Cyrus;Crawford, Gabriel;Doering, Angela;Dominiczak, Anna;Doney, Alex S. F.;Ebrahim, Shah;Elliott, Paul;Erdos, Michael R.;Estrada, Karol;Ferrucci, Luigi;Fischer, Guido;Forouhi, Nita G.;Gieger, Christian;Grallert, Harald;Groves, Christopher J.;Grundy, Scott;Guiducci, Candace;Hadley, David;Hamsten, Anders;Havulinna, Aki S.;Holle, Rolf;Holloway, John W.;Illig, Thomas;Isomaa, Bo;Jacobs, Leonie C.;Jameson, Karen;Jousilahti, Pekka;Karpe, Fredrik;Kuusisto, Johanna;Laitinen, Jaana;Lathrop, G. Mark;Lawlor, Debbie A.;Mangino, Massimo;McArdle, Wendy L.;Meitinger, Thomas;Morken, Mario A.;Morris, Andrew P.;Munroe, Patricia;Narisu, Narisu;Nordström, Anna;Nordström, Peter;Oostra, Ben A.;Palmer, Colin N. A.;Payne, Felicity;Peden, John F.;Prokopenko, Inga;Renström, Frida;Ruokonen, Aimo;Salomaa, Veikko;Sandhu, Manjinder S.;Scuteri, Angelo;Silander, Kaisa;Song, Kijoung;Stringham, Heather M.;Swift, Amy J.;Tuomi, Tiinamaija;Uda, Manuela;Vollenweider, Peter;Waeber, Gerard;Wallace, Chris;Walters, G. Bragi;Weedon, Michael N.;Witteman, Jacqueline C. M.;Zhang, Cuilin;Zhang, Weihua;Caulfield, Mark J.;Collins, Francis S.;Davey Smith, George;Day, Ian N. M.;Franks, Paul W.;Hattersley, Andrew T.;Jarvelin, Marjo-Riitta;Kong, Augustine;Kooner, Jaspal S.;Laakso, Markku;Lakatta, Edward;Mooser, Vincent;Morris, Andrew D.;Peltonen, Leena;Samani, Nilesh J.;Spector, Timothy D.;Strachan, David P.;Tanaka, Toshiko;Tuomilehto, Jaakko;Uitterlinden, André G.;van Duijn, Cornelia M.;Wareham, Nicholas J.;Waterworth, Dawn M.;Boehnke, Michael;Deloukas, Panos;Groop, Leif;Thorsteinsdottir, Unnur;Schlessinger, David;Wichmann, H.-Erich;Frayling, Timothy M.;Abecasis, Gonçalo R.;Loos, Ruth J. F.;Stefansson, Kari;Mohlke, Karen L.;Barroso, Inês;Hirschhorn, Joel Naom;McCarthy, Mark I.;Watkins, Hugh;The Wellcome Trust Case Control Consortium;Hunter, David J.;Hu, Frank B.;Yuan, Xin;Scott, Laura J.;Hofman, Albert;Zhao, Jing Hua;Lyon, Helen N;Qi, Lu
subject: diabetes and endocrinology;Obesity;type 2 diabetes;complex traits;Genetics and Genomics
Year: 2009
Publisher: Public Library of Science
Description: To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist–hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9×\(10^{-11}\)) and MSRA (WC, P = 8.9×\(10^{-9}\)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6×\(10^{-8}\)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695778/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:4881565
Standard no: Lindgren, Cecilia M., Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, Lu Qi, Elizabeth K. Speliotes, et al. 2009. Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genetics 5(6): e1000508.
1553-7390
Appears in Collections:HMS Scholarly Articles

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