Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/26125
Title: Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Authors: Pattaro, Cristian;Köttgen, Anna;Teumer, Alexander;Böger, Carsten A.;Fuchsberger, Christian;Olden, Matthias;Chen, Ming-Huei;Tin, Adrienne;Taliun, Daniel;Li, Man;Gao, Xiaoyi;Gorski, Mathias;Yang, Qiong;Hundertmark, Claudia;Foster, Meredith C.;Glazer, Nicole;Isaacs, Aaron;Liu, Ching-Ti;Smith, Albert V.;O'Connell, Jeffrey R.;Struchalin, Maksim;Tanaka, Toshiko;Gierman, Hinco J.;Feitosa, Mary;Hwang, Shih-Jen;Atkinson, Elizabeth J.;Lohman, Kurt;Johansson, Åsa;Tönjes, Anke;Dehghan, Abbas;Chouraki, Vincent;Holliday, Elizabeth G.;Sorice, Rossella;Kutalik, Zoltan;Lehtimäki, Terho;Esko, Tõnu;Deshmukh, Harshal;Ulivi, Sheila;Murgia, Federico;Trompet, Stella;Imboden, Medea;Kollerits, Barbara;Pistis, Giorgio;Harris, Tamara B.;Launer, Lenore J.;Aspelund, Thor;Eiriksdottir, Gudny;Mitchell, Braxton D.;Boerwinkle, Eric;Schmidt, Helena;Cavalieri, Margherita;Rao, Madhumathi;Demirkan, Ayse;Oostra, Ben A.;de Andrade, Mariza;Ding, Jingzhong;Andrews, Jeanette S.;Freedman, Barry I.;Koenig, Wolfgang;Illig, Thomas;Döring, Angela;Wichmann, H.-Erich;Kolcic, Ivana;Zemunik, Tatijana;Boban, Mladen;Minelli, Cosetta;Wheeler, Heather E.;Igl, Wilmar;Zaboli, Ghazal;Wild, Sarah H.;Wright, Alan F.;Campbell, Harry;Ellinghaus, David;Nöthlings, Ute;Jacobs, Gunnar;Biffar, Reiner;Endlich, Karlhans;Ernst, Florian;Homuth, Georg;Kroemer, Heyo K.;Nauck, Matthias;Stracke, Sylvia;Völker, Uwe;Völzke, Henry;Kovacs, Peter;Stumvoll, Michael;Mägi, Reedik;Uitterlinden, Andre G.;Rivadeneira, Fernando;Aulchenko, Yurii S.;Polasek, Ozren;Hastie, Nick;Vitart, Veronique;Helmer, Catherine;Wang, Jie Jin;Ruggiero, Daniela;Bergmann, Sven;Kähönen, Mika;Viikari, Jorma;Nikopensius, Tiit;Province, Michael;Ketkar, Shamika;Colhoun, Helen;Doney, Alex;Robino, Antonietta;Giulianini, Franco;Krämer, Bernhard K.;Portas, Laura;Ford, Ian;Buckley, Brendan M.;Adam, Martin;Thun, Gian-Andri;Paulweber, Bernhard;Haun, Margot;Sala, Cinzia;Metzger, Marie;Mitchell, Paul;Ciullo, Marina;Kim, Stuart K.;Vollenweider, Peter;Raitakari, Olli;Metspalu, Andres;Palmer, Colin;Gasparini, Paolo;Pirastu, Mario;Jukema, J. Wouter;Probst-Hensch, Nicole M.;Kronenberg, Florian;Toniolo, Daniela;Gudnason, Vilmundur;Shuldiner, Alan R.;Coresh, Josef;Schmidt, Reinhold;Ferrucci, Luigi;Siscovick, David S.;van Duijn, Cornelia M.;Borecki, Ingrid;Kardia, Sharon L. R.;Liu, Yongmei;Rudan, Igor;Gyllensten, Ulf;Wilson, James F.;Franke, Andre;Pramstaller, Peter P.;Rettig, Rainer;Prokopenko, Inga;Witteman, Jacqueline C. M.;Hayward, Caroline;Parsa, Afshin;Bochud, Murielle;Heid, Iris M.;Garnaas, Maija;O'Seaghdha, Conall;Li, Guo;Johnson, Andrew D.;Cornelis, Marilyn;Chu, Audrey Yu-lei;Hu, Frank B.;Turner, Stephen T.;Hofman, Albert;Curhan, Gary Craig;Ridker, Paul M.;Goessling, Wolfram;Chasman, Daniel Ian;Kao, W. H. Linda;Fox, Caroline
subject: Biology;Genetics
Year: 2012
Publisher: Public Library of Science
Description: Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near \(MPPED2\), \(DDX1\), \(SLC47A1\), \(CDK12\), \(CASP9\), and \(INO80\). Morpholino knockdown of \(mpped2\) and \(casp9\) in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315455/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:9795487
Standard no: Pattaro, Cristian, Anna Köttgen, Alexander Teumer, Maija Garnaas, Carsten A. Böger, Christian Fuchsberger, Matthias Olden, et al. 2012. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics 8(3): e1002584.
1553-7390
Appears in Collections:HMS Scholarly Articles

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