Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/26533
Title: High Phobic Anxiety Is Related to Lower Leukocyte Telomere Length in Women
Authors: Okereke, Olivia Ifeoma;Prescott, Jennifer;Wong, Jason Yat Yang;Han, Jiali;Rexrode, Kathryn Marian;De Vivo, Immaculata
subject: Biology;Genetics;Human Genetics;Molecular Genetics;Genomics;Chromosome Biology;Telomeres;Molecular Cell Biology;Medicine;Mental Health;Psychiatry;Anxiety Disorders;Social and Behavioral Sciences;Psychology;Psychological Stress
Year: 2012
Publisher: Public Library of Science
Description: Background: Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety – phobic anxiety – is related to telomere length. Methodology/Principal Findings Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42–69 years) who: were participants in the Nurses' Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (z-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend = 0.09); this association was similar after adjustment for confounders – paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend = 0.15). Notably, a threshold was identified. Among women with Crown-Crisp<6 points, the multivariable-adjusted least-squares mean RTL z-score = 0.02 standard units; however, among the most phobic women (Crown-Crisp≥6), the multivariable-adjusted least-squares mean RTL z-score = −0.09 standard units (mean difference = −0.10 standard units; p = 0.02). The magnitude of this difference was comparable to that for women 6 years apart in age. Finally, effect modification by BMI, smoking and paternal age was observed: associations were stronger among highly phobic women with BMI≥25 kg/m2, without smoking history, or born to fathers aged ≥40 years. Conclusions/Significance: In this large, cross-sectional study high phobic anxiety was associated with shorter telomeres. These results point toward prospective investigations relating anxiety to telomere length change.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394740/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10437035
Standard no: Okereke, Olivia I., Jennifer Prescott, Jason Y. Y. Wong, Jiali Han, Kathryn M. Rexrode, and Immaculata De Vivo. 2012. High phobic anxiety is related to lower leukocyte telomere length in women. PLoS ONE 7(7): e40516.
1932-6203
Appears in Collections:HMS Scholarly Articles

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