Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/27603
Title: Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Authors: Scott, Robert A;Lagou, Vasiliki;Welch, Ryan P;Wheeler, Eleanor;Montasser, May E;Luan, Jian’an;Mägi, Reedik;Strawbridge, Rona J;Rehnberg, Emil;Gustafsson, Stefan;Kanoni, Stavroula;Rasmussen-Torvik, Laura J;Yengo, Loïc;Lecoeur, Cecile;Shungin, Dmitry;Sanna, Serena;Sidore, Carlo;Johnson, Paul C D;Jukema, J Wouter;Johnson, Toby;Mahajan, Anubha;Verweij, Niek;Thorleifsson, Gudmar;Hottenga, Jouke-Jan;Shah, Sonia;Smith, Albert V;Sennblad, Bengt;Gieger, Christian;Salo, Perttu;Perola, Markus;Timpson, Nicholas J;Evans, David M;Pourcain, Beate St;Wu, Ying;Andrews, Jeanette S;Hui, Jennie;Bielak, Lawrence F;Zhao, Wei;Horikoshi, Momoko;Navarro, Pau;Isaacs, Aaron;O’Connell, Jeffrey R;Stirrups, Kathleen;Vitart, Veronique;Hayward, Caroline;Esko, Tönu;Mihailov, Evelin;Fraser, Ross M;Fall, Tove;Voight, Benjamin F;Raychaudhuri, Soumya;Chen, Han;Lindgren, Cecilia M;Morris, Andrew P;Rayner, Nigel W;Robertson, Neil;Rybin, Denis;Liu, Ching-Ti;Beckmann, Jacques S;Willems, Sara M;Chines, Peter S;Jackson, Anne U;Kang, Hyun Min;Stringham, Heather M;Song, Kijoung;Tanaka, Toshiko;Peden, John F;Goel, Anuj;Hicks, Andrew A;An, Ping;Müller-Nurasyid, Martina;Franco-Cereceda, Anders;Folkersen, Lasse;Marullo, Letizia;Jansen, Hanneke;Oldehinkel, Albertine J;Bruinenberg, Marcel;Pankow, James S;North, Kari E;Forouhi, Nita G;Loos, Ruth J F;Edkins, Sarah;Varga, Tibor V;Hallmans, Göran;Oksa, Heikki;Antonella, Mulas;Nagaraja, Ramaiah;Trompet, Stella;Ford, Ian;Bakker, Stephan J L;Kong, Augustine;Kumari, Meena;Gigante, Bruna;Herder, Christian;Munroe, Patricia B;Caulfield, Mark;Antti, Jula;Mangino, Massimo;Small, Kerrin;Miljkovic, Iva;Liu, Yongmei;Atalay, Mustafa;Kiess, Wieland;James, Alan L;Rivadeneira, Fernando;Uitterlinden, Andre G;Palmer, Colin N A;Doney, Alex S F;Willemsen, Gonneke;Smit, Johannes H;Campbell, Susan;Polasek, Ozren;Bonnycastle, Lori L;Hercberg, Serge;Dimitriou, Maria;Bolton, Jennifer L;Fowkes, Gerard R;Kovacs, Peter;Lindström, Jaana;Zemunik, Tatijana;Bandinelli, Stefania;Wild, Sarah H;Basart, Hanneke V;Rathmann, Wolfgang;Grallert, Harald;Maerz, Winfried;Kleber, Marcus E;Boehm, Bernhard O;Peters, Annette;Pramstaller, Peter P;Province, Michael A;Borecki, Ingrid B;Hastie, Nicholas D;Rudan, Igor;Campbell, Harry;Watkins, Hugh;Farrall, Martin;Stumvoll, Michael;Ferrucci, Luigi;Waterworth, Dawn M;Bergman, Richard N;Collins, Francis S;Tuomilehto, Jaakko;Watanabe, Richard M;de Geus, Eco J C;Penninx, Brenda W;Hofman, Albert;Oostra, Ben A;Psaty, Bruce M;Vollenweider, Peter;Wilson, James F;Wright, Alan F;Hovingh, G Kees;Metspalu, Andres;Uusitupa, Matti;Magnusson, Patrik K E;Kyvik, Kirsten O;Kaprio, Jaakko;Price, Jackie F;Dedoussis, George V;Deloukas, Panos;Meneton, Pierre;Lind, Lars;Boehnke, Michael;Shuldiner, Alan R;van Duijn, Cornelia M;Morris, Andrew D;Toenjes, Anke;Peyser, Patricia A;Beilby, John P;Körner, Antje;Kuusisto, Johanna;Laakso, Markku;Bornstein, Stefan R;Schwarz, Peter E H;Lakka, Timo A;Rauramaa, Rainer;Adair, Linda S;Smith, George Davey;Spector, Tim D;Illig, Thomas;de Faire, Ulf;Hamsten, Anders;Gudnason, Vilmundur;Kivimaki, Mika;Hingorani, Aroon;Keinanen-Kiukaanniemi, Sirkka M;Saaristo, Timo E;Boomsma, Dorret I;Stefansson, Kari;van der Harst, Pim;Dupuis, Josée;Pedersen, Nancy L;Sattar, Naveed;Harris, Tamara B;Cucca, Francesco;Ripatti, Samuli;Salomaa, Veikko;Mohlke, Karen L;Balkau, Beverley;Froguel, Philippe;Pouta, Anneli;Jarvelin, Marjo-Riitta;Wareham, Nicholas J;Bouatia-Naji, Nabila;McCarthy, Mark I;Franks, Paul W;Meigs, James Benjamin;Teslovich, Tanya M;Florez, Jose Carlos;Langenberg, Claudia;Ingelsson, Erik;Prokopenko, Inga;Barroso, Inês
Year: 2012
Description: Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have raised the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional follow-up of these newly discovered loci will further improve our understanding of glycemic control.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3433394/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10642219
Standard no: Scott, Robert A, Vasiliki Lagou, Ryan P Welch, Eleanor Wheeler, May E Montasser, Jian’an Luan, Reedik Mägi, et al. 2012. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature genetics 44(9): 991-1005.
1061-4036
Appears in Collections:HMS Scholarly Articles

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.