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Title: No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Authors: Scott, Robert A.;Chu, Audrey Yu-lei;Grarup, Niels;Manning, Alisa K.;Hivert, Marie-France;Shungin, Dmitry;Tönjes, Anke;Yesupriya, Ajay;Barnes, Daniel;Bouatia-Naji, Nabila;Glazer, Nicole L.;Jackson, Anne U.;Kutalik, Zoltán;Lagou, Vasiliki;Marek, Diana;Rasmussen-Torvik, Laura J.;Stringham, Heather M.;Tanaka, Toshiko;Aadahl, Mette;Arking, Dan E.;Bergmann, Sven;Boerwinkle, Eric;Bonnycastle, Lori L.;Bornstein, Stefan R.;Brunner, Eric;Bumpstead, Suzannah J.;Brage, Soren;Carlson, Olga D.;Chen, Han;Chen, Yii-Der Ida;Chines, Peter S.;Collins, Francis S.;Couper, David J.;Dennison, Elaine M.;Dowling, Nicole F.;Egan, Josephine S.;Ekelund, Ulf;Erdos, Michael R.;Forouhi, Nita G.;Fox, Caroline;Goodarzi, Mark O.;Grässler, Jürgen;Gustafsson, Stefan;Hallmans, Göran;Hansen, Torben;Hingorani, Aroon;Holloway, John W.;Hu, Frank B.;Isomaa, Bo;Jameson, Karen A.;Johansson, Ingegerd;Jonsson, Anna;Jørgensen, Torben;Kivimaki, Mika;Kovacs, Peter;Kumari, Meena;Kuusisto, Johanna;Laakso, Markku;Lecoeur, Cécile;Lévy-Marchal, Claire;Li, Guo;Loos, Ruth J.F.;Lyssenko, Valeri;Marmot, Michael;Marques-Vidal, Pedro;Morken, Mario A.;Müller, Gabriele;North, Kari E.;Pankow, James S.;Payne, Felicity;Prokopenko, Inga;Psaty, Bruce M.;Renström, Frida;Rice, Ken;Rotter, Jerome I.;Rybin, Denis;Sandholt, Camilla H.;Sayer, Avan A.;Shrader, Peter;Schwarz, Peter E.H.;Siscovick, David S.;Stančáková, Alena;Stumvoll, Michael;Teslovich, Tanya M.;Waeber, Gérard;Williams, Gordon Harold;Witte, Daniel R.;Wood, Andrew R.;Xie, Weijia;Boehnke, Michael;Cooper, Cyrus;Ferrucci, Luigi;Froguel, Philippe;Groop, Leif;Kao, W.H. Linda;Vollenweider, Peter;Walker, Mark;Watanabe, Richard M.;Pedersen, Oluf;Meigs, James Benjamin;Ingelsson, Erik;Barroso, Inês;Florez, Jose Carlos;Franks, Paul W.;Dupuis, Josée;Wareham, Nicholas J.;Langenberg, Claudia
Year: 2012
Publisher: American Diabetes Association
Description: Gene–lifestyle interactions have been suggested to contribute to the development of type 2 diabetes. Glucose levels 2 h after a standard 75-g glucose challenge are used to diagnose diabetes and are associated with both genetic and lifestyle factors. However, whether these factors interact to determine 2-h glucose levels is unknown. We meta-analyzed single nucleotide polymorphism (SNP) × BMI and SNP × physical activity (PA) interaction regression models for five SNPs previously associated with 2-h glucose levels from up to 22 studies comprising 54,884 individuals without diabetes. PA levels were dichotomized, with individuals below the first quintile classified as inactive (20%) and the remainder as active (80%). BMI was considered a continuous trait. Inactive individuals had higher 2-h glucose levels than active individuals (β = 0.22 mmol/L [95% CI 0.13–0.31], P = 1.63 × 10−6). All SNPs were associated with 2-h glucose (β = 0.06–0.12 mmol/allele, P ≤ 1.53 × 10−7), but no significant interactions were found with PA (P > 0.18) or BMI (P ≥ 0.04). In this large study of gene–lifestyle interaction, we observed no interactions between genetic and lifestyle factors, both of which were associated with 2-h glucose. It is perhaps unlikely that top loci from genome-wide association studies will exhibit strong subgroup-specific effects, and may not, therefore, make the best candidates for the study of interactions.
Standard no: Scott, Robert A., Audrey Y. Chu, Niels Grarup, Alisa K. Manning, Marie-France Hivert, Dmitry Shungin, Anke Tönjes, et al. 2012. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes 61(5): 1291-1296.
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