Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/28179
Title: New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Authors: Horikoshi, Momoko;Yaghootkar, Hanieh;Mook-Kanamori, Dennis O.;Sovio, Ulla;Taal, H. Rob;Hennig, Branwen J.;Bradfield, Jonathan P.;St. Pourcain, Beate;Evans, David M.;Charoen, Pimphen;Kaakinen, Marika;Cousminer, Diana L.;Lehtimäki, Terho;Kreiner-Møller, Eskil;Warrington, Nicole M.;Bustamante, Mariona;Feenstra, Bjarke;Berry, Diane J.;Thiering, Elisabeth;Pfab, Thiemo;Barton, Sheila J.;Shields, Beverley M.;Kerkhof, Marjan;van Leeuwen, Elisabeth M.;Fulford, Anthony J.;Kutalik, Zoltán;Zhao, Jing Hua;den Hoed, Marcel;Mahajan, Anubha;Lindi, Virpi;Goh, Liang-Kee;Hottenga, Jouke-Jan;Wu, Ying;Raitakari, Olli T.;Harder, Marie N.;Meirhaeghe, Aline;Ntalla, Ioanna;Salem, Rany M.;Jameson, Karen A.;Zhou, Kaixin;Monies, Dorota M.;Lagou, Vasiliki;Kirin, Mirna;Heikkinen, Jani;Adair, Linda S.;Alkuraya, Fowzan S.;Al-Odaib, Ali;Amouyel, Philippe;Andersson, Ehm Astrid;Bennett, Amanda J.;Blakemore, Alexandra I.F.;Buxton, Jessica L.;Dallongeville, Jean;Das, Shikta;de Geus, Eco J. C.;Estivill, Xavier;Flexeder, Claudia;Froguel, Philippe;Geller, Frank;Godfrey, Keith M.;Gottrand, Frédéric;Groves, Christopher J.;Hansen, Torben;Hirschhorn, Joel N.;Hofman, Albert;Hollegaard, Mads V.;Hougaard, David M.;Hyppönen, Elina;Inskip, Hazel M.;Isaacs, Aaron;Jørgensen, Torben;Kanaka-Gantenbein, Christina;Kemp, John P.;Kiess, Wieland;Kilpeläinen, Tuomas O.;Klopp, Norman;Knight, Bridget A.;Kuzawa, Christopher W.;McMahon, George;Newnham, John P.;Niinikoski, Harri;Oostra, Ben A.;Pedersen, Louise;Postma, Dirkje S.;Ring, Susan M.;Rivadeneira, Fernando;Robertson, Neil R.;Sebert, Sylvain;Simell, Olli;Slowinski, Torsten;Tiesler, Carla M.T.;Tönjes, Anke;Vaag, Allan;Viikari, Jorma S.;Vink, Jacqueline M.;Vissing, Nadja Hawwa;Wareham, Nicholas J.;Willemsen, Gonneke;Witte, Daniel R.;Zhang, Haitao;Zhao, Jianhua;Wilson, James F.;Stumvoll, Michael;Prentice, Andrew M.;Meyer, Brian F.;Pearson, Ewan R.;Boreham, Colin A.G.;Cooper, Cyrus;Gillman, Matthew W.;Dedoussis, George V.;Moreno, Luis A;Pedersen, Oluf;Saarinen, Maiju;Mohlke, Karen L.;Boomsma, Dorret I.;Saw, Seang-Mei;Lakka, Timo A.;Körner, Antje;Loos, Ruth J.F.;Ong, Ken K.;Vollenweider, Peter;van Duijn, Cornelia M.;Koppelman, Gerard H.;Hattersley, Andrew T.;Holloway, John W.;Hocher, Berthold;Heinrich, Joachim;Power, Chris;Melbye, Mads;Guxens, Mònica;Pennell, Craig E.;Bønnelykke, Klaus;Bisgaard, Hans;Eriksson, Johan G.;Widén, Elisabeth;Hakonarson, Hakon;Uitterlinden, André G.;Pouta, Anneli;Lawlor, Debbie A.;Smith, George Davey;Frayling, Timothy M.;McCarthy, Mark I.;Grant, Struan F.A.;Jaddoe, Vincent W.V.;Jarvelin, Marjo-Riitta;Timpson, Nicholas J.;Prokopenko, Inga;Freathy, Rachel M.
Year: 2012
Description: Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood1. Previous genome-wide association studies identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes, and a second variant, near CCNL1, with no obvious link to adult traits2. In an expanded genome-wide association meta-analysis and follow-up study (up to 69,308 individuals of European descent from 43 studies), we have now extended the number of genome-wide significant loci to seven, accounting for a similar proportion of variance to maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes; ADRB1 with adult blood pressure; and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605762/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717515
Standard no: Horikoshi, M., H. Yaghootkar, D. O. Mook-Kanamori, U. Sovio, H. R. Taal, B. J. Hennig, J. P. Bradfield, et al. 2012. “New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.” Nature genetics 45 (1): 76-82. doi:10.1038/ng.2477. http://dx.doi.org/10.1038/ng.2477.
1061-4036
Appears in Collections:HMS Scholarly Articles

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