Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/28689
Title: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer
Authors: Pharoah, Paul D. P.;Tsai, Ya-Yu;Ramus, Susan J.;Phelan, Catherine M.;Goode, Ellen L.;Lawrenson, Kate;Price, Melissa;Fridley, Brooke L.;Tyrer, Jonathan P.;Shen, Howard;Weber, Rachel;Karevan, Rod;Larson, Melissa C.;Song, Honglin;Tessier, Daniel C.;Bacot, François;Vincent, Daniel;Cunningham, Julie M.;Dennis, Joe;Dicks, Ed;Aben, Katja K.;Anton-Culver, Hoda;Antonenkova, Natalia;Armasu, Sebastian M.;Baglietto, Laura;Bandera, Elisa V.;Beckmann, Matthias W.;Birrer, Michael J.;Bloom, Greg;Bogdanova, Natalia;Brenton, James D.;Brinton, Louise A.;Brooks-Wilson, Angela;Brown, Robert;Butzow, Ralf;Campbell, Ian;Carney, Michael E;Carvalho, Renato S.;Chang-Claude, Jenny;Chen, Y. Anne;Chen, Zhihua;Chow, Wong-Ho;Cicek, Mine S.;Coetzee, Gerhard;Cook, Linda S.;Cramer, Daniel W.;Cybulski, Cezary;Dansonka-Mieszkowska, Agnieszka;Despierre, Evelyn;Doherty, Jennifer A;Dörk, Thilo;du Bois, Andreas;Dürst, Matthias;Eccles, Diana;Edwards, Robert;Ekici, Arif B.;Fasching, Peter A.;Fenstermacher, David;Flanagan, James;Gao, Yu-Tang;Garcia-Closas, Montserrat;Gentry-Maharaj, Aleksandra;Giles, Graham;Gjyshi, Anxhela;Gore, Martin;Gronwald, Jacek;Guo, Qi;Halle, Mari K;Harter, Philipp;Hein, Alexander;Heitz, Florian;Hillemanns, Peter;Hoatlin, Maureen;Høgdall, Estrid;Høgdall, Claus K.;Hosono, Satoyo;Jakubowska, Anna;Jensen, Allan;Kalli, Kimberly R.;Karlan, Beth Y.;Kelemen, Linda E.;Kiemeney, Lambertus A.;Kjaer, Susanne Krüger;Konecny, Gottfried E.;Krakstad, Camilla;Kupryjanczyk, Jolanta;Lambrechts, Diether;Lambrechts, Sandrina;Le, Nhu D.;Lee, Nathan;Lee, Janet;Leminen, Arto;Lim, Boon Kiong;Lissowska, Jolanta;Lubiński, Jan;Lundvall, Lene;Lurie, Galina;Massuger, Leon F.A.G.;Matsuo, Keitaro;McGuire, Valerie;McLaughlin, John R;Menon, Usha;Modugno, Francesmary;Moysich, Kirsten B.;Nakanishi, Toru;Narod, Steven A.;Ness, Roberta B.;Nevanlinna, Heli;Nickels, Stefan;Noushmehr, Houtan;Odunsi, Kunle;Olson, Sara;Orlow, Irene;Paul, James;Pejovic, Tanja;Pelttari, Liisa M;Permuth-Wey, Jenny;Pike, Malcolm C;Poole, Elizabeth M;Qu, Xiaotao;Risch, Harvey A.;Rodriguez-Rodriguez, Lorna;Rossing, Mary Anne;Rudolph, Anja;Runnebaum, Ingo;Rzepecka, Iwona K;Salvesen, Helga B.;Schwaab, Ira;Severi, Gianluca;Shen, Hui;Shridhar, Vijayalakshmi;Shu, Xiao-Ou;Sieh, Weiva;Southey, Melissa C.;Spellman, Paul;Tajima, Kazuo;Teo, Soo-Hwang;Terry, Kathryn L.;Thompson, Pamela J;Timorek, Agnieszka;Tworoger, Shelley S.;van Altena, Anne M.;Berg, David Van Den;Vergote, Ignace;Vierkant, Robert A.;Vitonis, Allison F.;Wang-Gohrke, Shan;Wentzensen, Nicolas;Whittemore, Alice S.;Wik, Elisabeth;Winterhoff, Boris;Woo, Yin Ling;Wu, Anna H;Yang, Hannah P.;Zheng, Wei;Ziogas, Argyrios;Zulkifli, Famida;Goodman, Marc T.;Hall, Per;Easton, Douglas F;Pearce, Celeste L;Berchuck, Andrew;Chenevix-Trench, Georgia;Iversen, Edwin;Monteiro, Alvaro N.A.;Gayther, Simon A.;Schildkraut, Joellen M.;Sellers, Thomas A.
Year: 2013
Description: Genome wide association studies (GWAS) have identified four susceptibility loci for epithelial ovarian cancer (EOC) with another two loci being close to genome-wide significance. We pooled data from a GWAS conducted in North America with another GWAS from the United Kingdom. We selected the top 24,551 SNPs for inclusion on the iCOGS custom genotyping array. Follow-up genotyping was carried out in 18,174 cases and 26,134 controls from 43 studies from the Ovarian Cancer Association Consortium. We validated the two loci at 3q25 and 17q21 previously near genome-wide significance and identified three novel loci associated with risk; two loci associated with all EOC subtypes, at 8q21 (rs11782652, P=5.5×10-9) and 10p12 (rs1243180; P=1.8×10-8), and another locus specific to the serous subtype at 17q12 (rs757210; P=8.1×10-10). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility that implicates CHMP4C in the pathogenesis of ovarian cancer.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693183/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11878839
Standard no: Pharoah, P. D. P., Y. Tsai, S. J. Ramus, C. M. Phelan, E. L. Goode, K. Lawrenson, M. Price, et al. 2013. “GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.” Nature genetics 45 (4): 362-370e2. doi:10.1038/ng.2564. http://dx.doi.org/10.1038/ng.2564.
1061-4036
Appears in Collections:HMS Scholarly Articles

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