Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/29288
Title: CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Authors: Bradshaw, Elizabeth M;Chibnik, Lori B;Keenan, Brendan T;Ottoboni, Linda;Raj, Towfique;Tang, Anna;Rosenkrantz, Laura L;Imboywa, Selina;Lee, Michelle;Von Korff, Alina;Morris, Martha C;Evans, Denis A;Johnson, Keith;Sperling, Reisa A;Schneider, Julie A;Bennett, David A;De Jager, Philip L
Year: 2013
Description: In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703870/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879590
Standard no: Bradshaw, E. M., L. B. Chibnik, B. T. Keenan, L. Ottoboni, T. Raj, A. Tang, L. L. Rosenkrantz, et al. 2013. “CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology.” Nature neuroscience 16 (7): 10.1038/nn.3435. doi:10.1038/nn.3435. http://dx.doi.org/10.1038/nn.3435.
1097-6256
Appears in Collections:HMS Scholarly Articles

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