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Title: CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Authors: Bradshaw, Elizabeth M;Chibnik, Lori B;Keenan, Brendan T;Ottoboni, Linda;Raj, Towfique;Tang, Anna;Rosenkrantz, Laura L;Imboywa, Selina;Lee, Michelle;Von Korff, Alina;Morris, Martha C;Evans, Denis A;Johnson, Keith;Sperling, Reisa A;Schneider, Julie A;Bennett, David A;De Jager, Philip L
Year: 2013
Description: In our functional dissection of the CD33 Alzheimer’s disease susceptibility locus, we find that the rs3865444C risk allele is associated with greater cell surface expression of CD33 in monocytes (t50 = 10.06, pjoint=1.3×10–13) of young and older individuals. It is also associated with (1) diminished internalization of Aβ42) (2) accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging and (3), increased numbers of activated human microglia.
Standard no: Bradshaw, E. M., L. B. Chibnik, B. T. Keenan, L. Ottoboni, T. Raj, A. Tang, L. L. Rosenkrantz, et al. 2013. “CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology.” Nature neuroscience 16 (7): 10.1038/nn.3435. doi:10.1038/nn.3435.
Appears in Collections:HMS Scholarly Articles

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