Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/29821
Title: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Authors: Berndt, Sonja I.;Gustafsson, Stefan;Mägi, Reedik;Ganna, Andrea;Wheeler, Eleanor;Feitosa, Mary F.;Justice, Anne E.;Monda, Keri L.;Croteau-Chonka, Damien C.;Day, Felix R.;Esko, Tõnu;Fall, Tove;Ferreira, Teresa;Gentilini, Davide;Jackson, Anne U.;Luan, Jian’an;Randall, Joshua C.;Vedantam, Sailaja;Willer, Cristen J.;Winkler, Thomas W.;Wood, Andrew R.;Workalemahu, Tsegaselassie;Hu, Yi-Juan;Lee, Sang Hong;Liang, Liming;Lin, Dan-Yu;Min, Josine L.;Neale, Benjamin M.;Thorleifsson, Gudmar;Yang, Jian;Albrecht, Eva;Amin, Najaf;Bragg-Gresham, Jennifer L.;Cadby, Gemma;den Heijer, Martin;Eklund, Niina;Fischer, Krista;Goel, Anuj;Hottenga, Jouke-Jan;Huffman, Jennifer E.;Jarick, Ivonne;Johansson, Åsa;Johnson, Toby;Kanoni, Stavroula;Kleber, Marcus E.;König, Inke R.;Kristiansson, Kati;Kutalik, Zoltán;Lamina, Claudia;Lecoeur, Cecile;Li, Guo;Mangino, Massimo;McArdle, Wendy L.;Medina-Gomez, Carolina;Müller-Nurasyid, Martina;Ngwa, Julius S.;Nolte, Ilja M.;Paternoster, Lavinia;Pechlivanis, Sonali;Perola, Markus;Peters, Marjolein J.;Preuss, Michael;Rose, Lynda M.;Shi, Jianxin;Shungin, Dmitry;Smith, Albert Vernon;Strawbridge, Rona J.;Surakka, Ida;Teumer, Alexander;Trip, Mieke D.;Tyrer, Jonathan;Van Vliet-Ostaptchouk, Jana V.;Vandenput, Liesbeth;Waite, Lindsay L.;Zhao, Jing Hua;Absher, Devin;Asselbergs, Folkert W.;Atalay, Mustafa;Attwood, Antony P.;Balmforth, Anthony J.;Basart, Hanneke;Beilby, John;Bonnycastle, Lori L.;Brambilla, Paolo;Bruinenberg, Marcel;Campbell, Harry;Chasman, Daniel I.;Chines, Peter S.;Collins, Francis S.;Connell, John M.;Cookson, William;de Faire, Ulf;de Vegt, Femmie;Dei, Mariano;Dimitriou, Maria;Edkins, Sarah;Estrada, Karol;Evans, David M.;Farrall, Martin;Ferrario, Marco M.;Ferrières, Jean;Franke, Lude;Frau, Francesca;Gejman, Pablo V.;Grallert, Harald;Grönberg, Henrik;Gudnason, Vilmundur;Hall, Alistair S.;Hall, Per;Hartikainen, Anna-Liisa;Hayward, Caroline;Heard-Costa, Nancy L.;Heath, Andrew C.;Hebebrand, Johannes;Homuth, Georg;Hu, Frank B.;Hunt, Sarah E.;Hyppönen, Elina;Iribarren, Carlos;Jacobs, Kevin B.;Jansson, John-Olov;Jula, Antti;Kähönen, Mika;Kathiresan, Sekar;Kee, Frank;Khaw, Kay-Tee;Kivimaki, Mika;Koenig, Wolfgang;Kraja, Aldi T.;Kumari, Meena;Kuulasmaa, Kari;Kuusisto, Johanna;Laitinen, Jaana H.;Lakka, Timo A.;Langenberg, Claudia;Launer, Lenore J.;Lind, Lars;Lindström, Jaana;Liu, Jianjun;Liuzzi, Antonio;Lokki, Marja-Liisa;Lorentzon, Mattias;Madden, Pamela A.;Magnusson, Patrik K.;Manunta, Paolo;Marek, Diana;März, Winfried;Mateo Leach, Irene;McKnight, Barbara;Medland, Sarah E.;Mihailov, Evelin;Milani, Lili;Montgomery, Grant W.;Mooser, Vincent;Mühleisen, Thomas W.;Munroe, Patricia B.;Musk, Arthur W.;Narisu, Narisu;Navis, Gerjan;Nicholson, George;Nohr, Ellen A.;Ong, Ken K.;Oostra, Ben A.;Palmer, Colin N.A.;Palotie, Aarno;Peden, John F.;Pedersen, Nancy;Peters, Annette;Polasek, Ozren;Pouta, Anneli;Pramstaller, Peter P.;Prokopenko, Inga;Pütter, Carolin;Radhakrishnan, Aparna;Raitakari, Olli;Rendon, Augusto;Rivadeneira, Fernando;Rudan, Igor;Saaristo, Timo E.;Sambrook, Jennifer G.;Sanders, Alan R.;Sanna, Serena;Saramies, Jouko;Schipf, Sabine;Schreiber, Stefan;Schunkert, Heribert;Shin, So-Youn;Signorini, Stefano;Sinisalo, Juha;Skrobek, Boris;Soranzo, Nicole;Stančáková, Alena;Stark, Klaus;Stephens, Jonathan C.;Stirrups, Kathleen;Stolk, Ronald P.;Stumvoll, Michael;Swift, Amy J.;Theodoraki, Eirini V.;Thorand, Barbara;Tregouet, David-Alexandre;Tremoli, Elena;Van der Klauw, Melanie M.;van Meurs, Joyce B.J.;Vermeulen, Sita H.;Viikari, Jorma;Virtamo, Jarmo;Vitart, Veronique;Waeber, Gérard;Wang, Zhaoming;Widén, Elisabeth;Wild, Sarah H.;Willemsen, Gonneke;Winkelmann, Bernhard R.;Witteman, Jacqueline C.M.;Wolffenbuttel, Bruce H.R.;Wong, Andrew;Wright, Alan F.;Zillikens, M. Carola;Amouyel, Philippe;Boehm, Bernhard O.;Boerwinkle, Eric;Boomsma, Dorret I.;Caulfield, Mark J.;Chanock, Stephen J.;Cupples, L. Adrienne;Cusi, Daniele;Dedoussis, George V.;Erdmann, Jeanette;Eriksson, Johan G.;Franks, Paul W.;Froguel, Philippe;Gieger, Christian;Gyllensten, Ulf;Hamsten, Anders;Harris, Tamara B.;Hengstenberg, Christian;Hicks, Andrew A.;Hingorani, Aroon;Hinney, Anke;Hofman, Albert;Hovingh, Kees G.;Hveem, Kristian;Illig, Thomas;Jarvelin, Marjo-Riitta;Jöckel, Karl-Heinz;Keinanen-Kiukaanniemi, Sirkka M.;Kiemeney, Lambertus A.;Kuh, Diana;Laakso, Markku;Lehtimäki, Terho;Levinson, Douglas F.;Martin, Nicholas G.;Metspalu, Andres;Morris, Andrew D.;Nieminen, Markku S.;Njølstad, Inger;Ohlsson, Claes;Oldehinkel, Albertine J.;Ouwehand, Willem H.;Palmer, Lyle J.;Penninx, Brenda;Power, Chris;Province, Michael A.;Psaty, Bruce M.;Qi, Lu;Rauramaa, Rainer;Ridker, Paul M.;Ripatti, Samuli;Salomaa, Veikko;Samani, Nilesh J.;Snieder, Harold;Sørensen, Thorkild I.A.;Spector, Timothy D.;Stefansson, Kari;Tönjes, Anke;Tuomilehto, Jaakko;Uitterlinden, André G.;Uusitupa, Matti;van der Harst, Pim;Vollenweider, Peter;Wallaschofski, Henri;Wareham, Nicholas J.;Watkins, Hugh;Wichmann, H.-Erich;Wilson, James F.;Abecasis, Goncalo R.;Assimes, Themistocles L.;Barroso, Inês;Boehnke, Michael;Borecki, Ingrid B.;Deloukas, Panos;Fox, Caroline S.;Frayling, Timothy;Groop, Leif C.;Haritunian, Talin;Heid, Iris M.;Hunter, David;Kaplan, Robert C.;Karpe, Fredrik;Moffatt, Miriam;Mohlke, Karen L.;O’Connell, Jeffrey R.;Pawitan, Yudi;Schadt, Eric E.;Schlessinger, David;Steinthorsdottir, Valgerdur;Strachan, David P.;Thorsteinsdottir, Unnur;van Duijn, Cornelia M.;Visscher, Peter M.;Di Blasio, Anna Maria;Hirschhorn, Joel N.;Lindgren, Cecilia M.;Morris, Andrew P.;Meyre, David;Scherag, André;McCarthy, Mark I.;Speliotes, Elizabeth K.;North, Kari E.;Loos, Ruth J.F.;Ingelsson, Erik
Year: 2014
Description: Approaches exploiting extremes of the trait distribution may reveal novel loci for common traits, but it is unknown whether such loci are generalizable to the general population. In a genome-wide search for loci associated with upper vs. lower 5th percentiles of body mass index, height and waist-hip ratio, as well as clinical classes of obesity including up to 263,407 European individuals, we identified four new loci (IGFBP4, H6PD, RSRC1, PPP2R2A) influencing height detected in the tails and seven new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3, ZZZ3) for clinical classes of obesity. Further, we show that there is large overlap in terms of genetic structure and distribution of variants between traits based on extremes and the general population and little etiologic heterogeneity between obesity subgroups.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973018/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12152861
Standard no: Berndt, S. I., S. Gustafsson, R. Mägi, A. Ganna, E. Wheeler, M. F. Feitosa, A. E. Justice, et al. 2014. “Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.” Nature genetics 45 (5): 501-512. doi:10.1038/ng.2606. http://dx.doi.org/10.1038/ng.2606.
1061-4036
Appears in Collections:HMS Scholarly Articles

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