Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/30298
Title: Common variants associated with plasma triglycerides and risk for coronary artery disease
Authors: Do, Ron;Willer, Cristen J.;Schmidt, Ellen M.;Sengupta, Sebanti;Gao, Chi;Peloso, Gina M.;Gustafsson, Stefan;Kanoni, Stavroula;Ganna, Andrea;Chen, Jin;Buchkovich, Martin L.;Mora, Samia;Beckmann, Jacques S.;Bragg-Gresham, Jennifer L.;Chang, Hsing-Yi;Demirkan, Ayşe;Den Hertog, Heleen M.;Donnelly, Louise A.;Ehret, Georg B.;Esko, Tõnu;Feitosa, Mary F.;Ferreira, Teresa;Fischer, Krista;Fontanillas, Pierre;Fraser, Ross M.;Freitag, Daniel F.;Gurdasani, Deepti;Heikkilä, Kauko;Hyppönen, Elina;Isaacs, Aaron;Jackson, Anne U.;Johansson, Åsa;Johnson, Toby;Kaakinen, Marika;Kettunen, Johannes;Kleber, Marcus E.;Li, Xiaohui;Luan, Jian'an;Lyytikäinen, Leo-Pekka;Magnusson, Patrik K.E.;Mangino, Massimo;Mihailov, Evelin;Montasser, May E.;Müller-Nurasyid, Martina;Nolte, Ilja M.;O'Connell, Jeffrey R.;Palmer, Cameron D.;Perola, Markus;Petersen, Ann-Kristin;Sanna, Serena;Saxena, Richa;Service, Susan K.;Shah, Sonia;Shungin, Dmitry;Sidore, Carlo;Song, Ci;Strawbridge, Rona J.;Surakka, Ida;Tanaka, Toshiko;Teslovich, Tanya M.;Thorleifsson, Gudmar;Van den Herik, Evita G.;Voight, Benjamin F.;Volcik, Kelly A.;Waite, Lindsay L.;Wong, Andrew;Wu, Ying;Zhang, Weihua;Absher, Devin;Asiki, Gershim;Barroso, Inês;Been, Latonya F.;Bolton, Jennifer L.;Bonnycastle, Lori L;Brambilla, Paolo;Burnett, Mary S.;Cesana, Giancarlo;Dimitriou, Maria;Doney, Alex S.F.;Döring, Angela;Elliott, Paul;Epstein, Stephen E.;Eyjolfsson, Gudmundur Ingi;Gigante, Bruna;Goodarzi, Mark O.;Grallert, Harald;Gravito, Martha L.;Groves, Christopher J.;Hallmans, Göran;Hartikainen, Anna-Liisa;Hayward, Caroline;Hernandez, Dena;Hicks, Andrew A.;Holm, Hilma;Hung, Yi-Jen;Illig, Thomas;Jones, Michelle R.;Kaleebu, Pontiano;Kastelein, John J.P.;Khaw, Kay-Tee;Kim, Eric;Klopp, Norman;Komulainen, Pirjo;Kumari, Meena;Langenberg, Claudia;Lehtimäki, Terho;Lin, Shih-Yi;Lindström, Jaana;Loos, Ruth J.F.;Mach, François;McArdle, Wendy L;Meisinger, Christa;Mitchell, Braxton D.;Müller, Gabrielle;Nagaraja, Ramaiah;Narisu, Narisu;Nieminen, Tuomo V.M.;Nsubuga, Rebecca N.;Olafsson, Isleifur;Ong, Ken K.;Palotie, Aarno;Papamarkou, Theodore;Pomilla, Cristina;Pouta, Anneli;Rader, Daniel J.;Reilly, Muredach P.;Ridker, Paul M.;Rivadeneira, Fernando;Rudan, Igor;Ruokonen, Aimo;Samani, Nilesh;Scharnagl, Hubert;Seeley, Janet;Silander, Kaisa;Stančáková, Alena;Stirrups, Kathleen;Swift, Amy J.;Tiret, Laurence;Uitterlinden, Andre G.;van Pelt, L. Joost;Vedantam, Sailaja;Wainwright, Nicholas;Wijmenga, Cisca;Wild, Sarah H.;Willemsen, Gonneke;Wilsgaard, Tom;Wilson, James F.;Young, Elizabeth H.;Zhao, Jing Hua;Adair, Linda S.;Arveiler, Dominique;Assimes, Themistocles L.;Bandinelli, Stefania;Bennett, Franklyn;Bochud, Murielle;Boehm, Bernhard O.;Boomsma, Dorret I.;Borecki, Ingrid B.;Bornstein, Stefan R.;Bovet, Pascal;Burnier, Michel;Campbell, Harry;Chakravarti, Aravinda;Chambers, John C.;Chen, Yii-Der Ida;Collins, Francis S.;Cooper, Richard S.;Danesh, John;Dedoussis, George;de Faire, Ulf;Feranil, Alan B.;Ferrières, Jean;Ferrucci, Luigi;Freimer, Nelson B.;Gieger, Christian;Groop, Leif C.;Gudnason, Vilmundur;Gyllensten, Ulf;Hamsten, Anders;Harris, Tamara B.;Hingorani, Aroon;Hirschhorn, Joel N.;Hofman, Albert;Hovingh, G. Kees;Hsiung, Chao Agnes;Humphries, Steve E.;Hunt, Steven C.;Hveem, Kristian;Iribarren, Carlos;Järvelin, Marjo-Riitta;Jula, Antti;Kähönen, Mika;Kaprio, Jaakko;Kesäniemi, Antero;Kivimaki, Mika;Kooner, Jaspal S.;Koudstaal, Peter J.;Krauss, Ronald M.;Kuh, Diana;Kuusisto, Johanna;Kyvik, Kirsten O.;Laakso, Markku;Lakka, Timo A.;Lind, Lars;Lindgren, Cecilia M.;Martin, Nicholas G.;März, Winfried;McCarthy, Mark I.;McKenzie, Colin A.;Meneton, Pierre;Metspalu, Andres;Moilanen, Leena;Morris, Andrew D.;Munroe, Patricia B.;Njølstad, Inger;Pedersen, Nancy L.;Power, Chris;Pramstaller, Peter P.;Price, Jackie F.;Psaty, Bruce M.;Quertermous, Thomas;Rauramaa, Rainer;Saleheen, Danish;Salomaa, Veikko;Sanghera, Dharambir K.;Saramies, Jouko;Schwarz, Peter E.H.;Sheu, Wayne H-H;Shuldiner, Alan R.;Siegbahn, Agneta;Spector, Tim D.;Stefansson, Kari;Strachan, David P.;Tayo, Bamidele O.;Tremoli, Elena;Tuomilehto, Jaakko;Uusitupa, Matti;van Duijn, Cornelia M.;Vollenweider, Peter;Wallentin, Lars;Wareham, Nicholas J.;Whitfield, John B.;Wolffenbuttel, Bruce H.R.;Altshuler, David;Ordovas, Jose M.;Boerwinkle, Eric;Palmer, Colin N.A.;Thorsteinsdottir, Unnur;Chasman, Daniel I.;Rotter, Jerome I.;Franks, Paul W.;Ripatti, Samuli;Cupples, L. Adrienne;Sandhu, Manjinder S.;Rich, Stephen S.;Boehnke, Michael;Deloukas, Panos;Mohlke, Karen L.;Ingelsson, Erik;Abecasis, Goncalo R.;Daly, Mark J.;Neale, Benjamin M.;Kathiresan, Sekar
Year: 2013
Description: Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiologic studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P<5×10−8 for each) to examine the role of triglycerides on risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglycerides, and show that the direction and magnitude of both are factors in determining CAD risk. Second, we consider loci with only a strong magnitude of association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol, a polymorphism's strength of effect on triglycerides is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904346/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406861
Standard no: Do, R., C. J. Willer, E. M. Schmidt, S. Sengupta, C. Gao, G. M. Peloso, S. Gustafsson, et al. 2013. “Common variants associated with plasma triglycerides and risk for coronary artery disease.” Nature genetics 45 (11): 1345-1352. doi:10.1038/ng.2795. http://dx.doi.org/10.1038/ng.2795.
1061-4036
Appears in Collections:HMS Scholarly Articles

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