Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/33339
Title: Genome-wide association analysis identifies three new breast cancer susceptibility loci
Authors: Ghoussaini, Maya;Fletcher, Olivia;Michailidou, Kyriaki;Turnbull, Clare;Schmidt, Marjanka K;Dicks, Ed;Dennis, Joe;Wang, Qin;Humphreys, Manjeet K;Luccarini, Craig;Baynes, Caroline;Conroy, Don;Maranian, Melanie;Ahmed, Shahana;Driver, Kristy;Johnson, Nichola;Orr, Nicholas;Silva, Isabel dos Santos;Waisfisz, Quinten;Meijers-Heijboer, Hanne;Uitterlinden, Andre G.;Rivadeneira, Fernando;Hall, Per;Czene, Kamila;Irwanto, Astrid;Liu, Jianjun;Nevanlinna, Heli;Aittomäki, Kristiina;Blomqvist, Carl;Meindl, Alfons;Schmutzler, Rita K;Müller-Myhsok, Bertram;Lichtner, Peter;Chang-Claude, Jenny;Hein, Rebecca;Nickels, Stefan;Flesch-Janys, Dieter;Tsimiklis, Helen;Makalic, Enes;Schmidt, Daniel;Bui, Minh;Hopper, John L;Apicella, Carmel;Park, Daniel J;Southey, Melissa;Hunter, David J.;Chanock, Stephen J;Broeks, Annegien;Verhoef, Senno;Hogervorst, Frans BL;Fasching, Peter A.;Lux, Michael P.;Beckmann, Matthias W.;Ekici, Arif B.;Sawyer, Elinor;Tomlinson, Ian;Kerin, Michael;Marme, Frederik;Schneeweiss, Andreas;Sohn, Christof;Burwinkel, Barbara;Guénel, Pascal;Truong, Thérèse;Cordina-Duverger, Emilie;Menegaux, Florence;Bojesen, Stig E;Nordestgaard, Børge G;Nielsen, Sune F;Flyger, Henrik;Milne, Roger L.;Alonso, M. Rosario;González-Neira, Anna;Benítez, Javier;Anton-Culver, Hoda;Ziogas, Argyrios;Bernstein, Leslie;Dur, Christina Clarke;Brenner, Hermann;Müller, Heiko;Arndt, Volker;Stegmaier, Christa;Justenhoven, Christina;Brauch, Hiltrud;Brüning, Thomas;Wang-Gohrke, Shan;Eilber, Ursula;Dörk, Thilo;Schürmann, Peter;Bremer, Michael;Hillemanns, Peter;Bogdanova, Natalia V.;Antonenkova, Natalia N.;Rogov, Yuri I.;Karstens, Johann H.;Bermisheva, Marina;Prokofieva, Darya;Khusnutdinova, Elza;Lindblom, Annika;Margolin, Sara;Mannermaa, Arto;Kataja, Vesa;Kosma, Veli-Matti;Hartikainen, Jaana M;Lambrechts, Diether;Yesilyurt, Betul T.;Floris, Giuseppe;Leunen, Karin;Manoukian, Siranoush;Bonanni, Bernardo;Fortuzzi, Stefano;Peterlongo, Paolo;Couch, Fergus J;Wang, Xianshu;Stevens, Kristen;Lee, Adam;Giles, Graham G.;Baglietto, Laura;Severi, Gianluca;McLean, Catriona;Alnæs, Grethe Grenaker;Kristensen, Vessela;Børrensen-Dale, Anne-Lise;John, Esther M.;Miron, Alexander;Winqvist, Robert;Pylkäs, Katri;Jukkola-Vuorinen, Arja;Kauppila, Saila;Andrulis, Irene L.;Glendon, Gord;Mulligan, Anna Marie;Devilee, Peter;van Asperen, Christie J.;Tollenaar, Rob A.E.M.;Seynaeve, Caroline;Figueroa, Jonine D;Garcia-Closas, Montserrat;Brinton, Louise;Lissowska, Jolanta;Hooning, Maartje J.;Hollestelle, Antoinette;Oldenburg, Rogier A.;van den Ouweland, Ans M.W.;Cox, Angela;Reed, Malcolm WR;Shah, Mitul;Jakubowska, Ania;Lubinski, Jan;Jaworska, Katarzyna;Durda, Katarzyna;Jones, Michael;Schoemaker, Minouk;Ashworth, Alan;Swerdlow, Anthony;Beesley, Jonathan;Chen, Xiaoqing;Muir, Kenneth R;Lophatananon, Artitaya;Rattanamongkongul, Suthee;Chaiwerawattana, Arkom;Kang, Daehee;Yoo, Keun-Young;Noh, Dong-Young;Shen, Chen-Yang;Yu, Jyh-Cherng;Wu, Pei-Ei;Hsiung, Chia-Ni;Perkins, Annie;Swann, Ruth;Velentzis, Louiza;Eccles, Diana M;Tapper, Will J;Gerty, Susan M;Graham, Nikki J;Ponder, Bruce A. J.;Chenevix-Trench, Georgia;Pharoah, Paul D.P.;Lathrop, Mark;Dunning, Alison M.;Rahman, Nazneen;Peto, Julian;Easton, Douglas F
Year: 2013
Description: Breast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for ~ 8% of the heritability of the disease. We followed up 72 promising associations from two independent Genome Wide Association Studies (GWAS) in ~70,000 cases and ~68,000 controls from 41 case-control studies and nine breast cancer GWAS. We identified three new breast cancer risk loci on 12p11 (rs10771399; P=2.7 × 10−35), 12q24 (rs1292011; P=4.3×10−19) and 21q21 (rs2823093; P=1.1×10−12). SNP rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) plays a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, while NRIP1 (21q21) encodes an ER co-factor and has a role in the regulation of breast cancer cell growth.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653403/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11370694
Standard no: Ghoussaini, Maya, Olivia Fletcher, Kyriaki Michailidou, Clare Turnbull, Marjanka K Schmidt, Ed Dicks, Joe Dennis, et al. 2013. Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature genetics 44(3): 312-318.
1061-4036
Appears in Collections:HSPH Scholarly Articles

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