Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/33747
Title: The Relationship between Inflammatory Biomarkers and Telomere Length in an Occupational Prospective Cohort Study
Authors: Wong, Jason Y. Y.;De Vivo, Immaculata;Lin, Xihong;Fang, Shona C.;Christiani, David C.
subject: Biology;Biochemistry;Nucleic Acids;Genetics;Human Genetics;Molecular Genetics;Population Genetics;Genomics;Chromosome Biology;Telomeres;Structural Genomics;Immunology;Immune Response;Mathematics;Statistics;Biostatistics;Medicine;Clinical Immunology;Clinical Research Design;Cohort Studies;Epidemiology;Longitudinal Studies;Observational Studies
Year: 2014
Publisher: Public Library of Science
Description: Background: Chronic inflammation from recurring trauma is an underlying pathophysiological basis of numerous diseases. Furthermore, it may result in cell death, scarring, fibrosis, and loss of tissue function. In states of inflammation, subsequent increases in oxidative stress and cellular division may lead to the accelerated erosion of telomeres, crucial genomic structures which protect chromosomes from decay. However, the association between plasma inflammatory marker concentrations and telomere length has been inconsistent in previous studies. Objective: The purpose of this study was to determine the longitudinal association between telomere length and plasma inflammatory biomarker concentrations including: CRP, SAA, sICAM-1, sVCAM-1, VEGF, TNF-α, IL-1β, IL-2, IL-6, IL-8, and IL-10. Methods: The longitudinal study population consisted of 87 subjects. The follow-up period was approximately 2 years. Plasma inflammatory biomarker concentrations were assessed using highly sensitive electrochemiluminescent assays. Leukocyte relative telomere length was assessed using Real-Time qPCR. Linear mixed effects regression models were used to analyze the association between repeated-measurements of relative telomere length as the outcome and each inflammatory biomarker concentration as continuous exposures separately. The analyses controlled for major potential confounders and white blood cell differentials. Results: At any follow-up time, each incremental ng/mL increase in plasma CRP concentration was associated with a decrease in telomere length of −2.6×10−2 (95%CI: −4.3×10−2, −8.2×10−3, p = 0.004) units. Similarly, the estimate for the negative linear association between SAA and telomere length was −2.6×10−2 (95%CI:−4.5×10−2, −6.1×10−3, p = 0.011). No statistically significant associations were observed between telomere length and plasma concentrations of pro-inflammatory interleukins, TNF-α, and VEGF. Conclusions: Findings from this study suggest that increased systemic inflammation, consistent with vascular injury, is associated with decreased leukocyte telomere length.
URI: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903646/pdf/
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879503
Standard no: Wong, Jason Y. Y., Immaculata De Vivo, Xihong Lin, Shona C. Fang, and David C. Christiani. 2014. “The Relationship between Inflammatory Biomarkers and Telomere Length in an Occupational Prospective Cohort Study.” PLoS ONE 9 (1): e87348. doi:10.1371/journal.pone.0087348. http://dx.doi.org/10.1371/journal.pone.0087348.
1932-6203
Appears in Collections:HSPH Scholarly Articles

Files in This Item:
Click on the URI links for accessing contents.


Items in HannanDL are protected by copyright, with all rights reserved, unless otherwise indicated.