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Title: Prophylaxis of experimental endocarditis with antiplatelet and antithrombin agents: a role for long-term prevention of infective endocarditis in humans?
Authors: Veloso, Tiago Rafael;Que, Yok-Ai;Chaouch, Aziz;Giddey, Marlyse;Vouillamoz, Jacques;Rousson, Valentin;Moreillon, Philippe;Entenza, José Manuel
Year: 1-Jan-2015
Abstract: Infective endocarditis (IE) mostly occurs after spontaneous low-grade bacteremia. Thus, IE cannot be prevented by circumstantial antibiotic prophylaxis. Platelet activation following bacterial-fibrinogen interaction or thrombin-mediated fibrinogen-fibrin polymerization is a critical step in vegetation formation. We tested the efficacy of antiplatelet and antithrombin to prevent experimental IE.
ISSN: 10.1093/infdis/jiu426
Appears in Collections:journal of infection disease 2015

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