Please use this identifier to cite or link to this item: http://dl.umsu.ac.ir/handle/Hannan/60489
Title: Interleukin-22 in kidney injury and regeneration
Authors: Weidenbusch, Marc;Rodler, Severin;Anders, Hans-Joachim
Year: 15-May-2015
Abstract: Interleukins have become well-known regulators of innate and adaptive immunity-related tissue inflammation. Recently, IL-22 has gained a lot of interest for its unique functions in maintaining and regaining epithelial integrity. IL-22 is exclusively secreted by different immune cell subsets, while IL-22 receptors are mainly expressed by epithelial cells. As the kidney is largely an epithelial organ, the functional role of IL-22 in the kidney deserves to be explored in detail. Here, we briefly summarize the key features of IL-22 biology and review the available data on its expression and functional roles in kidney injury and kidney regeneration. Furthermore, we provide suggestions on how to explore this evolving field in the future.
URI: http://dl.umsu.ac.ir/handle/Hannan/60489
ISSN: 10.1152/ajprenal.00005.2015
Appears in Collections:American journal of physiology renal physiology 2015

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